PCB congener profile in the serum of humans consuming Great Lakes fish

被引:93
作者
Humphrey, HEB
Gardiner, JC
Pandya, JR
Sweeney, AM
Gasior, DM
McCaffrey, RJ
Schantz, SL
机构
[1] Univ Illinois, Coll Vet Med, Dept Vet Biosci, Dept Psychol & Neurosci Program, Urbana, IL 61802 USA
[2] Michigan State Univ, Inst Environm Toxicol, E Lansing, MI 48824 USA
[3] Michigan State Univ, Dept Epidemiol, Coll Human Med, E Lansing, MI 48824 USA
[4] Univ Texas, Hlth Sci Ctr, Sch Publ Hlth, Houston, TX USA
[5] SUNY Albany, Dept Psychol, Albany, NY USA
关键词
aging; capillary column gas chromatography; fish-eaters; Great Lakes; Lake Michigan; polychlorinated biphenyl (PCB) congener profile;
D O I
10.2307/3454516
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The State of Michigan has a long history of research into human exposure to environmental contaminants through consumption of recreationally caught fish. A large cohort of Lake Michigan residents who eat fish (fish-eaters) and those who do not eat fish (nonfish-eaters) established in 1980 served as the basis for the congener-specific polychlorinated biphenyl (PCB) exposure evaluation reported here. In this paper we present the serum PCB congener profile for a subset of this cohort who were over 50 years of age. Serum samples were collected in 1993-1995 and were evaluated by a dual column capillary column gas chromatography procedure capable of detecting over 90 PCB congeners. This evaluation demonstrated significant PCB exposure in the fish-eaters (mean serum PCB of 14.26 ppb; n = 101). This elevated exposure allowed the establishment of a derailed profile of the PCB congeners found in humans exposed by this route. Twenty-two congeners of varying concentrations were the most prevalent and constituted over 95% of the total PCB present in most subjects. Four congeners, 138/163 (2,2',3,4,4',5-PCB/2,3,3',4',5,6-PCB), 180 (2,2',3,4,4',5,5'-PCB), and 153 (2,2',4,4',5,5'-PCB), accounted for 55-64% of the total PCB lend. Other congeners, some of toxicologic significance, were also detected by this analytical protocol. Nonfish-eaters had lower total serum PCB levels (mean = 4.56; n = 78), but the same general pattern of PCB congeners was present. It was demonstrated that careful selection of a subset of prevalent PCB congeners could provide a cost-effective assessment of exposure without losing critical scientific information.
引用
收藏
页码:167 / 172
页数:6
相关论文
共 27 条
[1]   Profiles of great lakes critical pollutants: A sentinel analysis of human blood and urine [J].
Anderson, HA ;
Falk, C ;
Hanrahan, L ;
Olson, J ;
Burse, VW ;
Needham, L ;
Paschal, D ;
Patterson, D ;
Hill, RH .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1998, 106 (05) :279-289
[2]   POLYCHLOROBIPHENYL (PCB) CONGENERS, P,P'-DDE, AND HEXACHLOROBENZENE IN MATERNAL AND FETAL CORD BLOOD FROM MOTHERS IN UPSTATE NEW-YORK [J].
BUSH, B ;
SNOW, J ;
KOBLINTZ, R .
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1984, 13 (05) :517-527
[3]  
DeVoto E, 1997, AM J IND MED, V32, P606, DOI 10.1002/(SICI)1097-0274(199712)32:6<606::AID-AJIM6>3.0.CO
[4]  
2-N
[5]  
*EPA, 1980, EPA600880038
[6]  
FLORE BJ, 1989, ARCH ENVIRON HEALTH, V44, P82
[7]   Concentrations of blood and hair mercury and serum PCBs in an Ojibwa population that consumes Great Lakes region fish [J].
Gerstenberger, SL ;
Tavris, DR ;
Hansen, LK ;
PrattShelley, J ;
Dellinger, JA .
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 1997, 35 (04) :377-386
[8]   Stepping backward to improve assessment of PCB congener toxicities [J].
Hansen, LG .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1998, 106 :171-189
[9]  
HANSEN LG, 1999, OCCURANCE DISPOSITIO
[10]   HISTORICAL CHANGES IN SERUM PCB AND DDT LEVELS IN AN ENVIRONMENTALLY-EXPOSED COHORT [J].
HOVINGA, ME ;
SOWERS, MF ;
HUMPHREY, HEB .
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1992, 22 (04) :362-366