Cancer cachexia

被引：97

作者：

Fearon, KCH ^{[1
]}

Moses, AGW ^{[1
]}

机构：

[1] Royal Infirm Edinburgh NHS Trust, Dept Clin & Surg Sci Surg, Edinburgh EH3 9YW, Midlothian, Scotland

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2002年 / 85卷 / 01期

关键词：

cancer; cachexia; weight loss; multimodal therapy;

D O I：

10.1016/S0167-5273(02)00235-8

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Cancer cachexia is a complex, multifactorial syndrome that results from a reduction in food intake, a variety of metabolic abnormalities (including hypermetabolism) or more often a combination of the two. Multiple mediator pathways including pro-inflammatory cytokines, neuroendocrine hormones and tumour-specific factors are involved. Therapy requires a multi-model approach that addresses both reduced food intake and metabolic change. Combination treatments such as nutritional support plus metabolic/inflammation modulation promise improved functional capacity and quality of life. (C) 2002 Published by Elsevier Science Ireland Ltd.

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收藏

页码：73 / 81

页数：9

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