CD56 positive intestinal T-cell lymphoma: Treatment with high dose chemotherapy and autologous peripheral blood stem cell transplantation

被引：17

作者：

Okuda, M ^{[1
]}

Nomura, J ^{[1
]}

Tateno, H ^{[1
]}

Kameoka, J ^{[1
]}

Sasaki, T ^{[1
]}

机构：

[1] Miyagi Canc Ctr, Dept Internal Med, Natori, Miyagi 9811293, Japan

来源：

INTERNAL MEDICINE | 2002年 / 41卷 / 09期

关键词：

natural killer cell-like; perforation of jejunem; jejunostomy; autologous peripheral blood stem cell; transplantation;

D O I：

10.2169/internalmedicine.41.734

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 63-year-old man presented with a perforation of the small intestine. A diagnosis of intestinal T-cell lymphoma (ITCL) was made from CD (cluster differentiation) 3 positivity and a rearrangement of T-cell receptor genes. The tumor also expressed CD56, which suggests it belongs to a rare subtype derived from activated cytotoxic intraepithelial T lymphocytes. Although the prognosis of ITCL has been considered to be very poor irrespective of CD56 positivity, complete remission was achieved in this case by high dose chemotherapy followed by autologous peripheral blood stem cell transplantation (auto-PBSCT) even after relapse. Auto-PBSCT in the earlier stage of the disease might improve the prognosis.

引用

页码：734 / 737

页数：4

共 15 条

[1] High-dose therapy with autologous stem cell transplantation in patients with peripheral T cell lymphomas [J].

Blystad, AK ;

Enblad, G ;

Kvaloy, S ;

Berglund, Å ;

Delabie, J ;

Holte, H ;

Carlson, K ;

Kvalheim, G ;

Bengtsson, M ;

Hagberg, H .

BONE MARROW TRANSPLANTATION, 2001, 27 (07) :711-716

[2]

Chim CS, 2001, CANCER, V91, P525, DOI 10.1002/1097-0142(20010201)91:3<525::AID-CNCR1030>3.0.CO

[3]

2-U

[4]

CHOTT A, 1992, AM J PATHOL, V141, P1361

[5] Most CD56+ intestinal lymphomas are CD8+CD5- T-cell lymphomas of monomorphic small to medium size histology [J].

Chott, A ;

Haedicke, W ;

Mosberger, I ;

Födinger, M ;

Winkler, K ;

Mannhalter, C ;

Müller-Hermelink, HK .

AMERICAN JOURNAL OF PATHOLOGY, 1998, 153 (05) :1483-1490

[6] PRIMARY LYMPHOMA OF THE SMALL-INTESTINE - A CLINICOPATHOLOGICAL STUDY OF 119 CASES [J].

DOMIZIO, P ;

OWEN, RA ;

SHEPHERD, NA ;

TALBOT, IC ;

NORTON, AJ .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1993, 17 (05) :429-442

[7] Enteropathy-type intestinal T-cell lymphoma: Clinical features and treatment of 31 patients in a single center [J].

Gale, J ;

Simmonds, PD ;

Mead, GM ;

Sweetenham, JW ;

Wright, DH .

JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (04) :795-803

[8] GASTROINTESTINAL LYMPHOMA [J].

ISAACSON, PG .

HUMAN PATHOLOGY, 1994, 25 (10) :1020-1029

[9] Gastrointestinal T cell lymphoma: Predominant cytotoxic phenotypes, including alpha/beta, gamma/delta T cell and natural killer cells [J].

Katoh, A ;

Ohshima, K ;

Kanda, M ;

Haraoka, S ;

Sugihara, M ;

Suzumiya, J ;

Kawasaki, C ;

Shimazaki, K ;

Ikeda, S ;

Kikuchi, M .

LEUKEMIA & LYMPHOMA, 2000, 39 (1-2) :97-111

[10] Effective high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation in a patient with the aggressive form of cytophagic histiocytic panniculitis [J].

Koizumi, K ;

Sawada, K ;

Nishio, M ;

Katagiri, E ;

Fukae, J ;

Fukada, Y ;

Tarumi, T ;

Notoya, A ;

Shimizu, T ;

Abe, R ;

Kobayashi, H ;

Koike, T .

BONE MARROW TRANSPLANTATION, 1997, 20 (02) :171-173

← 1 2 →