Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging

被引：107

作者：

Joseph, Danny K. ^{[1
]}

Huppert, Theodore J. ^{[1
]}

Franceschini, Maria Angela ^{[1
]}

Boas, David A. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Ctr Biomed Imaging, Dept Radiol,Massachusetts Gen Hosp, Charlestown, MA 02129 USA

来源：

APPLIED OPTICS | 2006年 / 45卷 / 31期

关键词：

D O I：

10.1364/AO.45.008142

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Although most current diffuse optical brain imaging systems use only nearest-neighbor measurement geometry, the spatial resolution and quantitative accuracy of the imaging can be improved through the collection of overlapping sets of measurements. A continuous-wave diffuse optical imaging system that combines frequency encoding with time-division multiplexing to facilitate overlapping measurements of brain activation is described. Phantom measurements to confirm the expected improvement in spatial resolution and quantitative accuracy are presented. Experimental results showing the application of this instrument for imaging human brain activation are also presented. The observed improvement in spatial resolution is confirmed by functional magnetic resonance imaging. (c) 2006 Optical Society of America.

引用

页码：8142 / 8151

页数：10

共 23 条

[1] Optical tomography in medical imaging [J].

Arridge, SR .

INVERSE PROBLEMS, 1999, 15 (02) :R41-R93

[2] Improving the diffuse optical imaging spatial resolution of the cerebral hemodynamic response to brain activation in humans [J].

Boas, DA ;

Chen, K ;

Grebert, D ;

Franceschini, MA .

OPTICS LETTERS, 2004, 29 (13) :1506-1508

[3] The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics [J].

Boas, DA ;

Gaudette, T ;

Strangman, G ;

Cheng, XF ;

Marota, JJA ;

Mandeville, JB .

NEUROIMAGE, 2001, 13 (01) :76-90

[4]

Chance B., 1993, P NATL ACAD SCI USA, V90, P2660

[5] SYSTEM FOR LONG-TERM MEASUREMENT OF CEREBRAL BLOOD AND TISSUE OXYGENATION ON NEWBORN-INFANTS BY NEAR-INFRARED TRANS-ILLUMINATION [J].

COPE, M ;

DELPY, DT .

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 1988, 26 (03) :289-294

[6]

Cox RW, 1999, MAGNET RESON MED, V42, P1014, DOI 10.1002/(SICI)1522-2594(199912)42:6<1014::AID-MRM4>3.0.CO

[7]

2-F

[8]

Dale AM, 1999, HUM BRAIN MAPP, V8, P109, DOI 10.1002/(SICI)1097-0193(1999)8:2/3<109::AID-HBM7>3.3.CO

[9]

2-N

[10] Incorporating a priori anatomical information into image reconstruction in electrical impedance tomography [J].

Dehghani, H ;

Barber, DC ;

Basarab-Horwath, I .

PHYSIOLOGICAL MEASUREMENT, 1999, 20 (01) :87-102

← 1 2 3 →