PINK, PANK, or PARK?: A clinicians' guide to familial parkinsonism

被引：41

作者：

Healy, DG

Abou-Sleiman, PM

Wood, NW

机构：

[1] Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England

[2] UCL Natl Hosp Neurol & Neurosurg, London WC1N 3BG, England

来源：

LANCET NEUROLOGY | 2004年 / 3卷 / 11期

关键词：

D O I：

10.1016/S1474-4422(04)00905-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We provide a pragmatic guide for clinicians, and detail the recent developments in the genetics of Parkinson's disease that have shaped our current understanding and management of this disease and other parkinsonian disorders. These developments have been rapid, and in total over 20 genes have been identified, three of which were discovered in the past year. Although there are undoubtedly more genes to be found, the major challenge for the future is to determine how they function and whether they interact. These genes help us to understand the heterogeneity of parkinsonism, and also inform on the molecular and clinical features of individual parkinsonisms. However, their discovery also requires us to raise issues about genetic testing and genetic counselling.

引用

页码：652 / 662

页数：11

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