Dissecting the functional role of different isoforms of the L-type Ca2+ channel

被引：14

作者：

Bourinet, E ^{[1
]}

Mangoni, ME ^{[1
]}

Nargeot, J ^{[1
]}

机构：

[1] CNRS, Unite Propre Rech 2580, Dept Physiol, Lab Genom Fonct, Montpellier, France

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 10期

关键词：

D O I：

10.1172/JCI200421815

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

There currently exist a great number of different mouse lines in which the activity of a particular gene of interest has been inactivated or enhanced. However, it is also possible to insert specific mutations in a gene so that the pharmacological sensitivity of the gene product is altered. An example of such an approach shows how the abolition of the sensitivity of an L-type Ca2+ channel isoform to dihydropyridines allows the investigation of the physiological role of these channels in different tissues (see the related article beginning on page 1430).

引用

页码：1382 / 1384

页数：3

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