Effects of Botulinum Toxin A on Patient-Specific Keloid Fibroblasts In Vitro

被引：62

作者：

Haubner, Frank ^{[1
]}

Leyh, Michaela ^{[1
]}

Ohmann, Elisabeth ^{[1
]}

Sadick, Haneen ^{[1
]}

Gassner, Holger G. ^{[1
]}

机构：

[1] Univ Regensburg, Dept Otorhinolaryngol, Lab Facial Plast Surg Res, D-93053 Regensburg, Germany

来源：

LARYNGOSCOPE | 2014年 / 124卷 / 06期

关键词：

Keloids; fibroblasts; botulinum toxin; cytokines; FACIAL WOUNDS; SCARS; GENE; IL-6; MICE; PATHOGENESIS; MANAGEMENT; PRIMATES; THERAPY; MODEL;

D O I：

10.1002/lary.24456

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Objectives/Hypothesis: To test whether therapeutic effects of botulinum toxin A on patient-specific keloid tissue can be reproduced on the cellular level. Specifically, effects on cell proliferation and expression of growth factors and cytokines relevant for wound healing were to be tested. Study Design: Experimental study including patient specific cell cultures of keloids. Methods: Patient-specific keloid tissue was tested in a cell culture model for effects of botulinum toxin incubation on cell proliferation and expression of the following cytokines and growth factors: IL-6 (interleukin-6), VEGF (vascular endothelial growth factor), TGF-beta (transforming growth factor-beta). Results: None of the tested parameters of human keloid tissue were affected by botulinum toxin A incubation. Conclusion: The present study does not add evidence to suggest a significant therapeutic role of botulinum toxin injections for the treatment of keloids.

引用

页码：1344 / 1351

页数：8

共 26 条

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