CD40-Associated TRAF 6 signaling is required for disease induction in a retrovirus-induced murine immunodeficiency

被引：8

作者：

Green, KA

Ahonen, CL

Cook, WJ

Green, WR

机构：

[1] Dartmouth Coll Sch Med, Dept Microbiol & Immunol, Lebanon, NH 03750 USA

[2] Norris Cotton Canc Ctr, Lebanon, NH 03756 USA

来源：

JOURNAL OF VIROLOGY | 2004年 / 78卷 / 11期

关键词：

D O I：

10.1128/JVI.78.11.6055-6060.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

LP-BMS retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.

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页码：6055 / 6060

页数：6

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