Anticonvulsion effect of acupuncture might be related to the decrease of neuronal and inducible nitric oxide synthases

被引：11

作者：

Yang, R ^{[1
]}

Huang, ZN ^{[1
]}

Cheng, JS ^{[1
]}

机构：

[1] Shanghai Med Univ, Dept Neurobiol, Inst Acupuncture Res, Natl Lab Med Neurobiol, Shanghai 200032, Peoples R China

来源：

ACUPUNCTURE & ELECTRO-THERAPEUTICS RESEARCH | 1999年 / 24卷 / 3-4期

关键词：

nitric oxide synthase (NOS); epilepsy; electroacupuncture (EA); hippocampus; RT-PCR;

D O I：

10.3727/036012999816356327

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

To measure the levels of hippocampal nitric oxide synthase isoforms in penicillin induced epilepsy and to test the effect of electroacupuncture (EA) on changes of these levels during epilepsy we injected penicillin into rat hippocampus to make an epilepsy model and performed electroacupuncture treatment on "Feng Fu" (DU 16) and "Jin Suo" (DU 8) points in Wistar rats. Nitric oxide synthase (NOS) mRNA levels of rat hippocampus were determined by reverse transcription-polymerase chain reaction (RT-PCR). The neuronal nitric oxide synthase (nNOS) mRNA markedly increased (p<0.01) and inducible nitric oxide synthase (iNOS) mRNA significantly emerged during epilepsy, whereas no significant change in epithelial nitric oxide synthase (eNOS) mRNA was observed. EA inhibited the epilepsy and decreased nNOS (p<0.01) and iNOS (p<0.01) correspondingly but had no effect on the amount of eNOS mRNA. The data suggest that penicillin-induced epilepsy caused an increase in nNOS and iNOS, and the EA anticonvulsant effect might be related to the decrease of these nitric oxide synthases.

引用

页码：161 / 167

页数：7

共 13 条

[1] KINDLING INDUCES A LONG-LASTING INCREASE IN BRAIN NITRIC-OXIDE SYNTHASE ACTIVITY [J].