Peptide fragments released from Phe-caseinomacropeptide in vivo in the rat

被引：23

作者：

Fosset, S

Fromentin, G

Gietzen, DW

Dubarry, M

Huneau, JF

Antoine, JM

Lang, V

Mathieu-Casseron, F

Tomé, D

机构：

[1] Inst Natl Agron Paris Grignon, Unite INRA, INAPG Physiol Nutr & Comportement Alimentaire, F-75231 Paris 05, France

[2] Danone Vitapole, F-92350 Le Plessis Robinson, France

[3] Univ Calif Davis, Dept Vet Med Anat Physiol & Cell Biol, Davis, CA 95616 USA

来源：

PEPTIDES | 2002年 / 23卷 / 10期

关键词：

Phe-caseinomacropeptide; caseinomacropeptide; pharmacokinetics; rat; peptide digestion; absorption;

D O I：

10.1016/S0196-9781(02)00134-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study was to investigate the pharmacokinetics of bovine Phe-caseinomacropeptide (Phe-CMP) in the rat after oral administration. This polypeptide was monophosphorylated and mainly nonglycosylated: Phe-CMP-IR During gastrointestinal digestion and absorption, Phe-CMP-1P was degraded. Intact Phe-CMP-1P and CMP-1P were rapidly released from the stomach. In contrast, partial hydrolysis by pancreatic enzymes was observed. In vitro hydrolysis by brush-border membrane vesicles also indicated that the peptide was degraded. In the blood, "CMP-immunoreactive material" appeared rapidly, reaching a maximum level of 5.5 mug/ml at 60 min. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：1773 / 1781

页数：9

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