Standardization of pahrmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs

被引：90

作者：

Mouton, JW

Dudley, MN

Cars, O

Derendorf, H

Drusano, GL

机构：

[1] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, NL-6532 SZ Nijmegen, Netherlands

[2] Essential Therapeut Inc, Mt View, CA USA

[3] Uppsala Univ, Dept Infect Dis, Uppsala, Sweden

[4] Univ Florida, Dept Pharmaceut, Gainesville, FL 32610 USA

[5] Albany Med Coll, Clin Res Inst, Div Clin Pharmacol, Albany, NY 12208 USA

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2002年 / 19卷 / 04期

关键词：

pharmacokinetic; pharmacodynamic; anti-infective drugs;

D O I：

10.1016/S0924-8579(02)00031-6

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Over the last decades, the interest in the relationships between the pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobial agents has increased and, therefore, the use of PK/PD indices and expressions has spread widely. The appropriate definition and use of these parameters is a matter of controversy. This paper contains a proposal to use PK/PD expressions for antimicrobial agents and their units in a uniform manner. (C) 2002 Published by Elsevier Science B.V. and International Society of Chemotherapy.

引用

页码：355 / 358

页数：4

共 11 条

[1] Determination of minimum inhibitory concentrations
Andrews, JM
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2001, 48 : 5 - 16
[2] Craig WA, 1996, ANTIBIOTICS LAB MED, P296
[3] COMPARATIVE PHARMACOKINETICS AND SERUM INHIBITORY ACTIVITY OF CLINDAMYCIN IN DIFFERENT DOSING REGIMENS
FLAHERTY, JF
RODONDI, LC
GUGLIELMO, BJ
FLEISHAKER, JC
TOWNSEND, RJ
GAMBERTOGLIO, JG
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (12) : 1825 - 1829
[4] Pharmacokinetics and pharmacodynamics of oral grepafloxacin in patients with acute bacterial exacerbations of chronic bronchitis
Forrest, A
Chodosh, S
Amantea, MA
Collins, DA
Schentag, JJ
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 40 : 45 - 57
[5] PHARMACODYNAMICS OF INTRAVENOUS CIPROFLOXACIN IN SERIOUSLY ILL-PATIENTS
FORREST, A
NIX, DE
BALLOW, CH
GOSS, TF
BIRMINGHAM, MC
SCHENTAG, JJ
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (05) : 1073 - 1081
[6] GRECO WR, 1995, PHARMACOL REV, V47, P331
[7] PHARMACOKINETIC AND PHARMACODYNAMIC ACTIVITIES OF CIPROFLOXACIN AGAINST STRAINS OF STREPTOCOCCUS-PNEUMONIAE, STAPHYLOCOCCUS-AUREUS, AND PSEUDOMONAS-AERUGINOSA FOR WHICH MICS ARE SIMILAR
HYATT, JM
NIX, DE
SCHENTAG, JJ
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (12) : 2730 - 2737
[8] National Committee for Clinical Laboratory Standards, 2000, M7A5 NCCLS
[9] Pharmacokinetics and pharmacodynamics of two multiple-dose piperacillin-tazobactam regimens
Occhipinti, DJ
Pendland, SL
Schoonover, LL
Rypins, EB
Danziger, LH
Rodvold, KA
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (11) : 2511 - 2517
[10] PHARMACODYNAMIC EFFECTS OF SUBINHIBITORY CONCENTRATIONS OF BETA-LACTAM ANTIBIOTICS INVITRO
ODENHOLTTORNQVIST, I
LOWDIN, E
CARS, O
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (09) : 1834 - 1839

← 1 2 →