CYP4A11 is repressed by retinoic acid in human liver cells

被引：21

作者：

Antoun, Joseph

Amet, Yolande

Simon, Brigitte

Dréano, Yvonne

Corlu, Anne

Corcos, Laurent

Salaun, Jean Pierre

Plée-Gautier, Emmanuelle

机构：

[1] Fac Med & Sci Sante, Biochim Lab, EA 948, F-29238 Brest 3, France

[2] CHU Pontchaillou, INSERM, U522, F-35033 Rennes, France

[3] CHU Morvan, INSERM, U613, Brest, France

[4] CNRS, UMR 7139, Biol Stn, F-29682 Roscoff, France

来源：

FEBS LETTERS | 2006年 / 580卷 / 14期

关键词：

cytochrome P450; retinoic acid; human hepatoma cells; HepaRG; fatty acid hydroxylase; liver;

D O I：

10.1016/j.febslet.2006.05.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CYP4A11, the major fatty acid omega-hydroxylase in human liver is involved in the balance of lipids, but its role and regulation are both poorly understood. We studied the effects of retinoids on the regulation of CYP4A11 in the human hepatoma cell line HepaRG. Treatment of HepaRG cells with all-trans-retinoic acid resulted in a strong decrease in CYP4A11 gene expression and apoprotein content and, furthermore, was associated with a 50% decrease in the microsomal lauric acid hydroxylation activity. Such a strong suppression of CYP4A11 expression by retinoids could have a major impact on fatty acid metabolism in the liver. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：3361 / 3367

页数：7

相关论文

共 46 条

[1] Retinoic acid modulates the cell-cycle in fetal rat hepatocytes and HepG2 cells by regulating cyclin-cdk activities [J].

Alisi, A ;

Leoni, S ;

Piacentani, A ;

Devirgiliis, LC .

LIVER INTERNATIONAL, 2003, 23 (03) :179-186

[2] RETINOIC ACID RECEPTORS AND RETINOID X-RECEPTORS - INTERACTIONS WITH ENDOGENOUS RETINOIC ACIDS [J].

ALLENBY, G ;

BOCQUEL, MT ;

SAUNDERS, M ;

KAZMER, S ;

SPECK, J ;

ROSENBERGER, M ;

LOVEY, A ;

KASTNER, P ;

GRIPPO, JF ;

CHAMBON, P ;

LEVIN, AA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (01) :30-34

[3] EVIDENCE THAT CYTOCHROME-P450 2E1 IS INVOLVED IN THE (OMEGA-1)-HYDROXYLATION OF LAURIC ACID IN RAT-LIVER MICROSOMES [J].

AMET, Y ;

BERTHOU, F ;

GOASDUFF, T ;

SALAUN, JP ;

LEBRETON, L ;

MENEZ, JF .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 203 (02) :1168-1174

[4] Validation of the (omega-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1 [J].

Amet, Y ;

Berthou, F ;

Baird, S ;

Dreano, Y ;

Bail, JP ;

Menez, JF .

BIOCHEMICAL PHARMACOLOGY, 1995, 50 (11) :1775-1782

[5] Simultaneous radiometric and fluorimetric detection of lauric acid metabolites using high-performance liquid chromatography following esterification with 4-bromomethyl-6,7-dimethoxycoumarin in human and rat liver microsomes [J].

Amet, Y ;

Berthou, F ;

Menez, JF .

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1996, 681 (02) :233-239

[6]

ANINAT C, 2005, DRUG METAB DISPOS

[7]

[Anonymous], CANC LETT

[8] INHIBITION BY RETINOIC ACID OF HEPATOCARCINOGENESIS INDUCED BY N-NITROSOMORPHOLINE AND OF EXPRESSION OF MYC ONCOGENE PROTEIN IN SPRAGUE-DAWLEY RATS [J].

BABA, M ;

IISHI, H ;

YAMAMOTO, R ;

TATSUTA, M .

INTERNATIONAL JOURNAL OF CANCER, 1991, 49 (03) :467-470

[9] Characterization of the CYNA11 gene, a second CYP4A gene in humans [J].

Bellamine, A ;

Wang, YR ;

Waterman, MR ;

Dawson, EP ;

Brown, NJ ;

Capdevila, JH .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2003, 409 (01) :221-227

[10] INVOLVEMENT OF CYTOCHROME-P450 3A ENZYME FAMILY IN THE MAJOR METABOLIC PATHWAYS OF TOREMIFENE IN HUMAN LIVER-MICROSOMES [J].

BERTHOU, F ;

DREANO, Y ;

BELLOC, C ;

KANGAS, L ;

GAUTIER, JC ;

BEAUNE, P .

BIOCHEMICAL PHARMACOLOGY, 1994, 47 (10) :1883-1895

← 1 2 3 4 5 →