Alteration of the LRP1B gene region is associated with high grade of urothelial cancer

被引：69

作者：

Langbein, S

Szakacs, O

Wilhelm, M

Sukosd, F

Weber, S

Jauch, A

Beltran, AL

Alken, P

Kälble, T

Kovacs, G

机构：

[1] Univ Heidelberg, Dept Urol, Mol Oncol Lab, D-69120 Heidelberg, Germany

[2] Univ Heidelberg, Inst Human Genet, D-69120 Heidelberg, Germany

[3] Univ Heidelberg, Dept Urol, Mannheim Clin, D-69120 Heidelberg, Germany

[4] Univ Cordoba, Dept Pathol, Cordoba, Spain

[5] Fulda Hosp, Dept Urol, Fulda, Germany

来源：

LABORATORY INVESTIGATION | 2002年 / 82卷 / 05期

关键词：

D O I：

10.1038/labinvest.3780458

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We have delineated regions of interest at chromosome 2q21.2, 2q36.3, and 2q37.1 by deletion mapping of 114 urothelial cancers (UC). Altogether, 17%, 18%, and 63% of the G1, G2, and G3 tumors displayed loss of heterozygosity at chromosome 2q, respectively, The region at 2q21.2 was narrowed down to the LRP1B gene (NT_005129.6). Hemi- and homozygous deletion at the LRP1B gene region was seen in 31 of 114 UCs. Only 8% of the UCs with G1 and none with G2 tumors showed loss of heterozygosity at the LRP1B gene, whereas 49% of the G3 UCs had allelic loss at this region. RT-PCR analysis of the LRP1B gene showed the lack of expression of several exons in 2 of 9 cases analyzed. Our analysis suggests that the LRP1B gene is a candidate tumor suppressor gene in UCs.

引用

页码：639 / 643

页数：5

共 23 条

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