Selective localization of cardiac SCN5A sodium channels in limbic regions of rat brain

被引：109

作者：

Hartmann, HA

Colom, LV

Sutherland, ML

Noebels, JL

机构：

[1] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Physiol & Mol Biophys, Houston, TX 77030 USA

来源：

NATURE NEUROSCIENCE | 1999年 / 2卷 / 07期

关键词：

D O I：

10.1038/10147

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Voltage-dependent sodium channels have a critical role in membrane electrogenesis and repetitive firing in excitable cells. Members of this gene superfamily exhibit diffuse, tissue-specific expression in nervous, muscle and cardiac tissues1. Tetrodotoxin (TTX) sensitivity and resistance to zinc blockade were thought to distinguish brain from heart sodium channels, but neuronal Na+ currents with heart-like properties have been found in brain2.

引用

收藏

页码：593 / 595

页数：3

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