Synthesis of a 2-aryisulphonylated tryptophan: The antibacterial activity of bovine lactoferricin peptides containing Trp(2-Pmc)

被引：13

作者：

Haug, BE

Andersen, J

Rekdal, O

Svendsen, JS ^{[1
]}

机构：

[1] Univ Tromso, Dept Chem, N-9037 Tromso, Norway

[2] Univ Tromso, Dept Biochem, N-9037 Tromso, Norway

来源：

JOURNAL OF PEPTIDE SCIENCE | 2002年 / 8卷 / 07期

关键词：

tryptophan; side-reaction of tryptophan; Pmc; antibacterial peptide; bovine lactoferricin;

D O I：

10.1002/psc.404

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A modified tryptophan, beta-[2(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-indol-3-yl]alanine, Trp(2-Pmc) = Tpe has been synthesized. Replacement of tryptophan in a bovine lactoferricin model peptide with the modified tryptophan resulted in peptides with a substantially increased antibacterial activity against Escherichia coli and Staphylococcus aureus. The most active peptides against each bacterial strain displayed minimal inhibitory concentrations of 7.5 mug/ml. Copyright (C) 2002 European Peptide Society and John Wiley Sons, Ltd.

引用

页码：307 / 313

页数：7

共 24 条

[1] TRIFLUOROACETYLATION OF AMINO-ACIDS AND PEPTIDES BY ETHYL TRIFLUOROACETATE [J].