Role of IL-23-Th17 Cell Axis in Allergic Airway Inflammation

被引：42

作者：

Wakashin, Hidefumi ^{[1
]}

Hirose, Koichi ^{[1
]}

Iwamoto, Itsuo ^{[2
]}

Nakajima, Hiroshi ^{[1
,3
]}

机构：

[1] Chiba Univ Hosp, Dept Allergy & Clin Immunol, Chiba 2608670, Japan

[2] Asahi Gen Hosp, Res Ctr Allergy & Clin Immunol, Chiba, Japan

[3] Chiba Univ, Grad Sch Med, Dept Mol Genet, Chiba, Japan

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2009年 / 149卷

关键词：

IL-23; Th17; cells; Asthma; Allergic inflammation; TGF-BETA; T-CELLS; IL-17; TH17; ASTHMA; INTERLEUKIN-17; INHALATION; EXPRESSION; INDUCTION; CYTOKINE;

D O I：

10.1159/000211382

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Asthma is characterized by chronic airway inflammation with intense eosinophil and lymphocyte infiltration, mucus hyperproduction, and airway hyperresponsiveness to a variety of stimuli. It is now generally accepted that antigen-specific Th2 cells and their cytokines orchestrate these pathognomonic features of asthma. On the other hand, Th17 cells and IL-23, a cytokine that preferentially expands Th17 cells, play a significant role in the development of chronic inflammatory diseases, including autoimmune diseases. Recently, we have shown that IL-23 and Th17 cells enhance not only neutrophilic airway inflammation but also Th2 cell-mediated eosinophilic airway inflammation in a murine asthma model. In this review, we will discuss the roles of IL-23 and Th17 cells in airway inflammation in asthma. Copyright (c) 2009 S. Karger AG, Basel

引用

页码：108 / 112

页数：5

共 31 条

[1] Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells [J].

Acosta-Rodriguez, Eva V. ;

Rivino, Laura ;

Geginat, Jens ;

Jarrossay, David ;

Gattorno, Marco ;

Lanzavecchia, Antonio ;

Sallusto, Federica ;

Napolitani, Giorgio .

NATURE IMMUNOLOGY, 2007, 8 (06) :639-646

[2] Evidence of a role of tumor necrosis factor α in refractory asthma [J].

Berry, MA ;

Hargadon, B ;

Shelley, M ;

Parker, D ;

Shaw, DE ;

Green, RH ;

Bradding, P ;

Brightling, CE ;

Wardlaw, AJ ;

Pavord, ID .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (07) :697-708

[3] Advances in immunology - Asthma [J].

Busse, WW ;

Lemanske, RF .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (05) :350-362

[4] Airway remodeling-associated mediators in moderate to severe asthma:: Effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression [J].

Chakir, J ;

Shannon, J ;

Molet, S ;

Fukakusa, M ;

Elias, J ;

Laviolette, M ;

Boulet, LP ;

Hamid, Q .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 111 (06) :1293-1298

[5] TH 17 cells in development:: an updated view of their molecular identity and genetic programming [J].

Dong, Chen .

NATURE REVIEWS IMMUNOLOGY, 2008, 8 (05) :337-348

[6] Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation [J].

Hansen, G ;

Berry, G ;

DeKruyff, RH ;

Umetsu, DT .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (02) :175-183

[7] Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae [J].

Happel, KI ;

Dubin, PJ ;

Zheng, MQ ;

Ghilardi, N ;

Lockhart, C ;

Quinton, LJ ;

Odden, AR ;

Shellito, JE ;

Bagby, GJ ;

Nelson, S ;

Kolls, JK .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (06) :761-769

[8] Resolvin E1 regulates interleukin 23, interferon-γ and lipoxin A4 to promote the resolution of allergic airway inflammation [J].

Haworth, Oliver ;

Cernadas, Manuela ;

Yang, Rong ;

Serhan, Charles N. ;

Levy, Bruce D. .

NATURE IMMUNOLOGY, 2008, 9 (08) :873-879

[9] Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge [J].

He, Rui ;

Oyoshi, Michiko K. ;

Jin, Haoli ;

Geha, Raif S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (40) :15817-15822

[10] Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma [J].

Hellings, PW ;

Kasran, A ;

Liu, ZJ ;

Vandekerckhove, P ;

Wuyts, A ;

Overbergh, L ;

Mathieu, C ;

Ceuppens, JL .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2003, 28 (01) :42-50

← 1 2 3 4 →