ERRγ: a Junior Orphan with a Senior Role in Metabolism

被引：96

作者：

Misra, Jagannath ^{[1
,2
]}

Kim, Don-Kyu ^{[3
]}

Choi, Hueng-Sik ^{[1
,2
]}

机构：

[1] Chonnam Natl Univ, Sch Biol Sci & Technol, Natl Creat Res Initiat Ctr Nucl Receptor Signals, Gwangju 61186, South Korea

[2] Chonnam Natl Univ, Sch Biol Sci & Technol, Hormone Res Ctr, Gwangju 61186, South Korea

[3] Chonnam Natl Univ, Dept Mol Biotechnol, Gwangju 61186, South Korea

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2017年 / 28卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

ESTROGEN-RELATED RECEPTORS; INDEPENDENT TRANSCRIPTIONAL ACTIVATION; GENE-EXPRESSION; STRUCTURAL BASIS; INVERSE AGONIST; SKELETAL-MUSCLE; KEY REGULATOR; ALPHA; SHP; HOMEOSTASIS;

D O I：

10.1016/j.tem.2016.12.005

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Estrogen-related receptor (ERR)gamma is an orphan nuclear hormone receptor that belongs to the ERR subfamily of transcription factors. No endogenous ligand has been identified to date. ERR gamma possesses ligand-independent transcriptional activity that is regulated by co-regulator interactions, and post-translational modifications (PTMs). Recent data from animal models have established ERR gamma as a crucial mediator of multiple endocrine and metabolic signals. ERR gamma plays important roles in pathological conditions such as insulin resistance, alcoholic liver injury, and cardiac hypertrophy, and controls energy metabolism in the heart, skeletal muscle, and pancreatic b cells. These findings corroborate the importance of ERR gamma in metabolic homeostasis, and suggest that ERR gamma is a good target for the treatment of metabolic diseases.

引用

收藏

页码：261 / 272

页数：12

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