iPS cells: a game changer for future medicine

被引：332

作者：

Inoue, Haruhisa ^{[1
,2
]}

Nagata, Naoki ^{[1
]}

Kurokawa, Hiromi ^{[1
]}

Yamanaka, Shinya ^{[1
,3
]}

机构：

[1] Kyoto Univ, Ctr iPS Cell Res & Applicat CiRA, Kyoto, Japan

[2] Japan Sci & Technol Agcy, JST CREST, Saitama, Japan

[3] Gladstone Inst Cardiovasc Dis, San Francisco, CA USA

来源：

EMBO JOURNAL | 2014年 / 33卷 / 05期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

cell transplantation; cohort study; disease modeling; future medicine; iPSC clinical trial; patient stratification; PLURIPOTENT STEM-CELLS; ALZHEIMERS-DISEASE; DIRECT CONVERSION; T-CELLS; FUNCTIONAL-NEURONS; HUMAN FIBROBLASTS; MOUSE; GENERATION; TRANSPLANTATION; INDUCTION;

D O I：

10.1002/embj.201387098

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The induced pluripotent stem cell (iPSC) technology is instrumental in advancing the fields of disease modeling and cell transplantation. We herein discuss the various issues regarding disease modeling and cell transplantation presented in previous reports, and also describe new iPSC-based medicine including iPSC clinical trials. In such trials, iPSCs from patients can be used to predict drug responders/non-responders by analyzing the efficacy of the drug on iPSC-derived cells. They could also be used to stratify patients after actual clinical trials, including those with sporadic diseases, based on the drug responsiveness of each patient in the clinical trials. iPSC-derived cells can be used for the identification of response markers, leading to increased success rates in such trials. Since iPSCs can be used in micromedicine for drug discovery, and in macromedicine for actual clinical trials, their use would tightly connect both micro- and macromedicine. The use of iPSCs in disease modeling, cell transplantation, and clinical trials could therefore lead to significant changes in the future of medicine.

引用

页码：409 / 417

页数：9

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