Dendritic spine plasticity in hippocampus

被引：36

作者：

Gazzaley, A

Kay, S

Benson, DL

机构：

[1] CUNY Mt Sinai Sch Med, Fishberg Res Ctr Neurobiol, New York, NY 10029 USA

[2] CUNY Mt Sinai Sch Med, Program Cell Adhes, New York, NY 10029 USA

来源：

NEUROSCIENCE | 2002年 / 111卷 / 04期

关键词：

estradiol; estrogen; long-term potentiation; synaptogenesis; spine density; excitatory synapses;

D O I：

10.1016/S0306-4522(02)00021-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Most excitatory input in the hippocampus and cerebral cortex impinges on dendritic spines. Alterations in dendritic spine density or shape are suspected to be morphological manifestations of changes in physiology or behavior. The links between spine plasticity and physiological responses have probably been best studied in the hippocampus in the context of changes in the circulating levels of steroid hormones or long-term potentiation. Here we review and present data which indicate that both the age of the preparation and the timing of the analysis can dramatically effect the results obtained. Collectively the data suggest that different cellular and morphological strategies may be utilized at different ages and under different circumstances to effect similar physiological responses or behaviors. (C) 2002 IBRO. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：853 / 862

页数：10

共 123 条

[1] Hippocampal dependent learning ability correlates with N-methyl-D-aspartate (NMDA) receptor levels in CA3 neurons of young and aged rats [J].