Intracerebroventricular injection of orexins does not stimulate food intake in neonatal chicks

被引:209
作者
Furuse, M [1 ]
Ando, R [1 ]
Bungo, T [1 ]
Ao, R [1 ]
Shimojo, M [1 ]
Masuda, Y [1 ]
机构
[1] Kyushu Univ, Fac Agr, Lab Anim Feed Sci, Fukuoka 8128581, Japan
关键词
D O I
10.1080/00071669987115
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
1. Recently, 2 novel neuropeptides were discovered, both derived from the same precursor by proteolytic professing, which bind and activate 2 closely related orphan G protein-coupled receptors, Named orexin-A and -B (Sakurai et at., 1998). Both stimulate food intake when administered centrally to rats. 2. Our aim was to elucidate whether central injection of mammalian orexin-A. or -B stimulates food intake in the chick. 3. Under conditions of free access to food, orexin-A did not alter the food intake of chicks, but cumulative food intake was significantly suppressed by orexin-B. 4. The orexin-B was then administered to chicks deprived of food for 3 h to confirm its; suppressive effect. No significant effect of orexin-B on food intake was detected. 5. Central injection of orexin-B did not modify food intake when appetite was stimulated, by fasting. 6. Neither of these orexins appears to stimulate feeding in chicks.
引用
收藏
页码:698 / 700
页数:3
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