Causes of Food-Induced Anaphylaxis in Italian Adults: A Multi-Centre Study

被引：124

作者：

Asero, R. ^{[1
]}

Antonicelli, L. ^{[2
]}

Arena, A. ^{[3
]}

Bommarito, L. ^{[4
]}

Caruso, B. ^{[5
]}

Colombo, G. ^{[7
]}

Crivellaro, M. ^{[6
]}

De Carli, M. ^{[8
]}

Della Torre, E. ^{[9
]}

Della Torre, F. ^{[9
]}

Heffler, E. ^{[4
]}

Rizzini, F. Lodi ^{[10
]}

Longo, R. ^{[11
]}

Manzotti, G. ^{[12
]}

Marcotulli, M. ^{[13
]}

Melchiorre, A. ^{[13
]}

Minale, P. ^{[14
]}

Morandi, P. ^{[15
]}

Moreni, B. ^{[13
]}

Moschella, A. ^{[16
]}

Murzilli, F. ^{[17
]}

Nebiolo, F. ^{[4
]}

Poppa, M. ^{[16
]}

Randazzo, S. ^{[18
]}

Rossi, G. ^{[19
]}

Senna, G. E. ^{[6
]}

机构：

[1] Clin San Carlo, Via Osped 21, IT-20037 Paderno Dugnano, Italy

[2] Osped Riuniti Bergamo, Serv Allergol, Ancona, Italy

[3] Azienda USL 5 Messina, Messina, Italy

[4] Azienda Osped Ordine Mauriziano, Turin, Italy

[5] Azienda Osped, Serv Chim Clin & Ematol, Verona, Italy

[6] Azienda Osped, UO Allergol, Verona, Italy

[7] IRCCS Fdn San Raffaele Monte Tabor, Allergy & Immunol Dept, Milan, Italy

[8] Univ Santa Maria Misericordia, Azienda Osped, Dipartimento Med Interna, Udine, Italy

[9] INRCA IRCCS UOC Pneumol Gen, UO Allergol, Casatenovo, Italy

[10] Spedali Civil Brescia, SSVD Allergol, I-25125 Brescia, Italy

[11] Azienda Sanit Prov, Vibo Valentia, Italy

[12] Azienda Osped, Treviglio, Italy

[13] Azienda Osped, UO Allergol, Desenzano Del Garda, Italy

[14] Osped San Martino Genova, Dipartimento Allergol, Genoa, Italy

[15] Osped Giussano, Azienda Osped Vimercate, Giussano, Italy

[16] ASL 14, Domodossola, Italy

[17] Osped SS Filippo & Nicola, UO Allergol, Avezzano, Italy

[18] ASL 2, Caltanissetta, Italy

[19] AUSL, Reggio Emilia, Italy

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2009年 / 150卷 / 03期

关键词：

Food-induced anaphylaxis; Food allergy; LIPID-TRANSFER PROTEIN; DOUBLE-BLIND; ALLERGY; CHILDREN; PEANUT; HYPERSENSITIVITY; IDENTIFICATION; SENSITIZATION; EMERGENCY; SYMPTOMS;

D O I：

10.1159/000222679

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Data about food-induced anaphylaxis in Italy are missing. Objective: It was the aim of this study to detect the main foods/food allergens causing anaphylaxis in Italy. Methods: The frequency of anaphylaxis and the relative importance of many offending foods were assessed in 1,110 adult patients with food allergy diagnosed by common criteria at 19 allergy centres scattered throughout Italy from 1 January to 31 December 2007. Results: Fifty-eight of 1,110 (5%) food-allergic patients experienced at least 1 episode of anaphylaxis. On average, they were older than other food-allergic patients (34 vs. 31 years; p < 0.05). The majority of anaphylactic episodes occurred in patients sensitized to lipid transfer protein (LTP; n = 19), followed by shrimp ( n = 10), tree nuts ( n = 9), legumes other than peanut ( n = 4), and seeds ( n = 2); peanut, spinach, celery, buckwheat, wheat, avocado, tomato, fish, meat, and Anisakis caused an anaphylactic reaction in single patients. Among LTP-hypersensitive patients, peach caused 13/19 anaphylactic episodes. Shrimp-allergic patients were significantly older than other patients with food-induced anaphylaxis (p < 0.05), whereas patients allergic to LTP experienced their anaphylactic episodes at a younger age (p < 0.001). The frequency of anaphylaxis among patients sensitized to LTP, shrimp or tree nuts did not differ between northern and central/southern Italy. Conclusion: LTP is the most important allergen causing food-induced anaphylaxis in Italy, peach being the most frequently offending food. Peanut-induced anaphylaxis seems very uncommon. Geographic and environmental differences both between Italy and other countries and within Italy seem to play a relevant role in the pattern of sensitization to foods. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：271 / 277

页数：7

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