CUT it out: silencing of noise in the transcriptome

被引：9

作者：

Lykke-Andersen, Soren ^{[1
]}

Jensen, Torben Heick ^{[1
]}

机构：

[1] Univ Aarhus, Dept Biol Mol, Ctr mRNP Biogenesis & Metab, Aarhus, Denmark

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2006年 / 13卷 / 10期

关键词：

D O I：

10.1038/nsmb1006-860

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eukaryotic transcriptomes are considerably larger than estimated from simple gene counts. However, much of this 'excess' RNA is immediately cleared from cells. Two recent studies reveal that so-called cryptic unstable transcripts constitutively transcribed from the yeast genome are rapidly eliminated in a process that couples transcription termination to RNA degradation.

引用

页码：860 / 861

页数：3

共 15 条

[1] Termination of cryptic unstable transcripts is directed by yeast RNA-Binding proteins Nrd1 and Nab3 [J].

Arigo, John T. ;

Eyler, Daniel E. ;

Carroll, Kristina L. ;

Corden, Jeffry L. .

MOLECULAR CELL, 2006, 23 (06) :841-851

[2] Regulation of yeast NRD1 expression by premature transcription termination [J].

Arigo, JT ;

Carroll, KL ;

Ames, JM ;

Corden, JL .

MOLECULAR CELL, 2006, 21 (05) :641-651

[3] Identification of cis elements directing termination of yeast nonpolyadenylated snoRNA transcripts [J].

Carroll, KL ;

Pradhan, DA ;

Granek, JA ;

Clarke, ND ;

Corden, JL .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (14) :6241-6252

[4] Accumulation of unstable promoter-associated transcripts upon loss of the nuclear exosome subunit Rrp6p in Saccharomyces cerevisiae [J].

Davis, CA ;

Ares, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (09) :3262-3267

[5] RNA-quality control by the exosome [J].

Houseley, Jonathan ;

LaCava, John ;

Tollervey, David .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (07) :529-539

[6] RNA degradation by the exosome is promoted by a nuclear polyade nylation complex [J].

LaCava, J ;

Houseley, J ;

Saveanu, C ;

Petfalski, E ;

Thompson, E ;

Jacquier, A ;

Tollervey, D .

CELL, 2005, 121 (05) :713-724

[7] Regulation of an intergenic transcript controls adjacent gene transcription in Saccharomyces cerevisiae [J].

Martens, JA ;

Wu, PYJ ;

Winston, F .

GENES & DEVELOPMENT, 2005, 19 (22) :2695-2704

[8] Formation of export-competent mRNP: escaping nuclear destruction [J].

Saguez, C ;

Olesen, JR ;

Jensen, TH .

CURRENT OPINION IN CELL BIOLOGY, 2005, 17 (03) :287-293

[9] Control of pre-mRNA accumulation by the essential yeast protein Nrd1 requires high-affinity transcript binding and a domain implicated in RNA polymerase II association [J].

Steinmetz, EJ ;

Brow, DA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (12) :6699-6704

[10] RNA-binding protein Nrd1 directs poly(A)-independent 3′-end formation of RNA polymerase II transcripts [J].

Steinmetz, EJ ;

Conrad, NK ;

Brow, DA ;

Corden, JL .

NATURE, 2001, 413 (6853) :327-331

← 1 2 →