New class of potent ligands for the human peripheral cannabinoid receptor

被引：87

作者：

Gallant, M

Dufresne, C

Gareau, Y

Guay, D

Leblanc, Y

Prasit, P

Rochette, C

Sawyer, N

Slipetz, DM

Tremblay, N

Metters, KM

Labelle, M

机构：

[1] Merck Frosst Ctr. for Therapeut. R., Dorval, Que. H9R 4P8

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 19期

关键词：

D O I：

10.1016/0960-894X(96)00426-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new class of potent ligand for the human peripheral cannabinoid (hCB(2)) receptor is described. Two indole analogs 13 and 17 exhibited nanomolar potencies (K-i) with good selectivity for the hCB(2) receptor over the human central cannabinoid (hCB(1)) receptor. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2263 / 2268

页数：6

共 32 条

[1] [Anonymous], J CLIN PHARMACOL
[2] ANTINOCICEPTIVE (AMINOALKYL)INDOLES
BELL, MR
DAMBRA, TE
KUMAR, V
EISSENSTAT, MA
HERRMANN, JL
WETZEL, JR
ROSI, D
PHILION, RE
DAUM, SJ
HLASTA, DJ
KULLNIG, RK
ACKERMAN, JH
HAUBRICH, DR
LUTTINGER, DA
BAIZMAN, ER
MILLER, MS
WARD, SJ
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (03) : 1099 - 1110
[3] ACYLATION OF THE ZINC SALT OF INDOLE
BERGMAN, J
VENEMALM, L
[J]. TETRAHEDRON, 1990, 46 (17) : 6061 - 6066
[4] NEW METHOD FOR METHYLATION OF AMINES
BORCH, RF
HASSID, AI
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1972, 37 (10) : 1673 - &
[5] BURSTEIN SH, 1989, Patent No. 4847290
[6] CAMPANELLA G, 1987, ANNU REV PHARMACOL, V27, P113
[7] DELTA-9-TETRAHYDROCANNABINOL AS AN ANTI-EMETIC IN CANCER-PATIENTS RECEIVING HIGH-DOSE METHOTREXATE - PROSPECTIVE, RANDOMIZED EVALUATION
CHANG, AE
SHILING, DJ
STILLMAN, RC
GOLDBERG, NH
SEIPP, CA
BAROFSKY, I
SIMON, RM
ROSENBERG, SA
[J]. ANNALS OF INTERNAL MEDICINE, 1979, 91 (06) : 819 - 824
[8] CONFORMATIONALLY RESTRAINED ANALOGS OF PRAVADOLINE - NANOMOLAR POTENT, ENANTIOSELECTIVE, (AMINOALKYL)INDOLE AGONISTS OF THE CANNABINOID RECEPTOR
DAMBRA, TE
ESTEP, KG
BELL, MR
EISSENSTAT, MA
JOSEF, KA
WARD, SJ
HAYCOCK, DA
BAIZMAN, ER
CASIANO, FM
BEGLIN, NC
CHIPPARI, SM
GREGO, JD
KULLNIG, RK
DALEY, GT
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (01) : 124 - 135
[9] DAMBRA TE, 1994, Patent No. 5324737
[10] DEVANE WA, 1988, MOL PHARMACOL, V34, P605

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