Ascorbic acid and beta-carotene as modulators of oxidative damage

被引：114

作者：

Cozzi, R ^{[1
]}

Ricordy, R ^{[1
]}

Aglitti, T ^{[1
]}

Gatta, V ^{[1
]}

Perticone, P ^{[1
]}

DeSalvia, R ^{[1
]}

机构：

[1] UNIV ROMA TRE, DIPARTIMENTO BIOL, ROME, ITALY

来源：

CARCINOGENESIS | 1997年 / 18卷 / 01期

关键词：

D O I：

10.1093/carcin/18.1.223

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Naturally occurring antioxidants are extensively studied for their capacity to protect organisms and cells from damage induced by oxygen reactive species. In fact, oxidative stress is considered a cause of aging, degenerative disease and cancer. We have focused our attention on two agents, ascorbic acid and beta-carotene, commonly considered to be antioxidants, but whose protective activity against cancer is insufficiently known. This paper reports on the ability of these agents to act against damage induced by H2O2 and bleomycin, in Chinese hamster ovary cells cultivated in vitro. Cytogenetic and cytofluorimetric analyses were performed. Both vitamins proved effective in reducing H2O2-induced sister chromatid exchanges, but increased H2O2- and bleomycin-induced chromosomal aberrations. Cytofluorimetric data, in contrast, showed that ascorbic acid and beta-carotene act as scavengers of endogeneous and H2O2-induced oxygen species.

引用

页码：223 / 228

页数：6

共 31 条

[1] IN-VIVO ANTIMUTAGENIC ACTIVITY OF BETA-CAROTENE IN RAT SPLEEN LYMPHOCYTES [J].