Manipulation of biological cells using a microelectromagnet matrix

被引：236

作者：

Lee, H ^{[1
]}

Purdon, AM

Westervelt, RM

机构：

[1] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA

[2] Harvard Univ, Div Engn & Appl Sci, Cambridge, MA 02138 USA

来源：

APPLIED PHYSICS LETTERS | 2004年 / 85卷 / 06期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1063/1.1776339

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Noninvasive manipulation of biological cells inside a microfluidic channel was demonstrated using a microelectromagnet matrix. The matrix consists of two layers of straight Au wires, aligned perpendicular to each other, that are covered by insulating layers. By adjusting the current in each independent wire, the microelectromagnet matrix can create versatile magnetic field patterns to control the motion of individual cells in fluid. Single or multiple yeast cells attached to magnetic beads were trapped, continuously moved and rotated, and a viable cell was separated from nonviable cells for cell sorting. (C) 2004 American Institute of Physics.

引用

收藏

页码：1063 / 1065

页数：3

相关论文

共 15 条

[1] Tissue Engineering at the Micro-Scale [J].

Bhatia, Sangeeta N. ;

Chen, Christopher S. .

BIOMEDICAL MICRODEVICES, 1999, 2 (02) :131-144

[2] An on-chip magnetic bead separator using spiral electromagnets with semi-encapsulated permalloy [J].

Choi, JW ;

Liakopoulos, TM ;

Ahn, CH .

BIOSENSORS & BIOELECTRONICS, 2001, 16 (06) :409-416

[3] THE PHYSICAL PROPERTIES OF CYTOPLASM - A STUDY BY MEANS OF THE MAGNETIC PARTICLE METHOD .1. EXPERIMENTAL [J].

CRICK, FHC ;

HUGHES, AFW .

EXPERIMENTAL CELL RESEARCH, 1950, 1 (01) :37-80

[4] Manipulation of magnetic microbeads in suspension using micromagnetic systems fabricated with soft lithography [J].

Deng, T ;

Whitesides, GM ;

Radhakrishnan, M ;

Zabow, G ;

Prentiss, M .

APPLIED PHYSICS LETTERS, 2001, 78 (12) :1775-1777

[5] Magnetic tweezers: Micromanipulation and force measurement at the molecular level [J].

Gosse, C ;

Croquette, V .

BIOPHYSICAL JOURNAL, 2002, 82 (06) :3314-3329

[6] Magnetic tweezers for DNA micromanipulation [J].

Haber, C ;

Wirtz, D .

REVIEW OF SCIENTIFIC INSTRUMENTS, 2000, 71 (12) :4561-4570

[7]

Hafeli U., 1997, Scientific and Clinical Applications of Magnetic Carriers, DOI DOI 10.1007/s10439-009-9660-y

[8] Microelectromagnets for the control of magnetic nanoparticles [J].

Lee, CS ;

Lee, H ;

Westervelt, RM .

APPLIED PHYSICS LETTERS, 2001, 79 (20) :3308-3310

[9] Mechanical properties of individual focal adhesions probed with a magnetic microneedle [J].

Matthews, BD ;

Overby, DR ;

Alenghat, FJ ;

Karavitis, J ;

Numaguchi, Y ;

Allen, PG ;

Ingber, DE .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 313 (03) :758-764

[10]

RADBRUCH A, 1994, METHOD CELL BIOL, V42, P387