MicroRNAs are novel biomarkers of colorectal cancer

被引：97

作者：

Aslam, M. I. ^{[1
]}

Taylor, K. ^{[1
]}

Pringle, J. H. ^{[1
]}

Jameson, J. S. ^{[1
]}

机构：

[1] Univ Hosp Leicester, Leicester Gen Hosp, Dept Colorectal Surg, Leicester, Leics, England

来源：

BRITISH JOURNAL OF SURGERY | 2009年 / 96卷 / 07期

关键词：

COLON-CANCER; TUMOR-SUPPRESSOR; SCREENING-PROGRAM; SMALL RNAS; EXPRESSION; GENE; IDENTIFICATION; TARGETS; GROWTH; CELLS;

D O I：

10.1002/bjs.6628

中图分类号：

R61 [外科手术学];

学科分类号：

100210 [外科学];

摘要：

Background: Recent studies have identified unique small ribonucleic acids called microRNAs (miRNAs) in colonic tumour tissue and blood that may accurately diagnose the presence of colorectal cancer and help predict disease recurrence. This review explores the potential role of these biomarkers. Methods: A literature search identified studies describing miRNAs in colorectal cancers. The outcomes of interest included diagnosis, progression and recurrence of disease, and future therapy. Results: Overexpression and silencing of specific miRNAs are associated with the development and progression of colorectal cancer. Such a role in oncogenesis suggest that miRNAs may be important targets for gene therapies. Differential expression of specific miRNAs in tissues and blood offers the prospect of their use in early detection and screening for colorectal cancer. miRNAs are implicated in metastasis and cytotoxic drug resistance. Their manipulation has potential in both prevention of recurrence and palliation. Conclusion: The miRNAs expression profile in tissue and blood has potential for their use in the detection, screening and surveillance of colorectal cancer. Furthermore, miRNAs may be targeted h gene therapy to treat colorectal cancer.

引用

页码：702 / 710

页数：9

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