Effects of Carbon Nanotubes on Human Monocytes

被引：12

作者：

De Nicola, Milena ^{[1
]}

Nuccitelli, Silvia ^{[1
]}

Gattia, Daniele Mirabile ^{[4
]}

Traversa, Enrico ^{[2
]}

Magrini, Andrea ^{[3
]}

Bergamaschi, Antonio ^{[5
]}

Ghibelli, Lina ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dipartimento Biol, Via Ric Sci, I-00133 Rome, Italy

[2] Univ Roma Tor Vergata, Dept Chem Sci & Technol, I-00133 Rome, Italy

[3] Univ Roma Tor Vergata, Dept Biopathol, I-00133 Rome, Italy

[4] Ente Nuove Tecnol Energia Ambiente, Div Nuovi Mat, Casaccia, Italy

[5] Catholic Univ, Inst Occupat Hlth Med, Rome, Italy

来源：

NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS | 2009年 / 1171卷

关键词：

cytotoxicity; MWCNT; human monocytes; apoptosis; CELL-PROLIFERATION; PULMONARY TOXICITY; CYTOTOXICITY; EXPOSURE; FIELD; MICE;

D O I：

10.1111/j.1749-6632.2009.04892.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Carbon nanotubes are considered to be one of the novel most attractive materials in nanotechnology. Because of their multiple industrial and biomedical applications, thorough studies on their toxicity and biocompatibility become a priority in order to prevent possible health risks. In this study the effects of multiwalled carbon nanotubes (MWCNT) on healthy monocytes from human peripheral blood were investigated. The results indicate that MWCNT exert a cytotoxic effect on monocytes, inducing cell death and increasing the extent of apoptosis induced by a chemotherapic agent. This cytotoxic effect may have important implications, and much attention in terms of evaluation of exposure risks is recommended.

引用

页码：600 / +

页数：3

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