Integrating cheminformatic analysis in combinatorial chemistry

被引：18

作者：

Blake, JF ^{[1
]}

机构：

[1] Array BioPharma Inc, Boulder, CO 80301 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2004年 / 8卷 / 04期

关键词：

D O I：

10.1016/j.cbpa.2004.04.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cheminformatic analysis of drug-related compound databases has enabled the identification of the physicochemical properties that have the greatest influence on determining the drug-like characteristics of a compound. This enables definition of the parameters and profiles used in constructing a high-quality combinatorial library. Awareness of the multi-objective nature of combinatorial library construction has also given rise to techniques designed to enhance the likelihood of including the best compounds in a given library.

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页码：407 / 411

页数：5

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