Transcriptional activating regions target a cyclin-dependent kinase

被引：48

作者：

Ansari, AZ

Koh, SS

Zaman, Z

Bongards, C

Lehming, N

Young, RA

Ptashne, M

机构：

[1] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Program Mol Biol, New York, NY 10021 USA

[2] Univ Wisconsin, Dept Biochem, Madison, WI 53705 USA

[3] Univ Wisconsin, Ctr Genome, Madison, WI 53705 USA

[4] MIT, Dept Biol, Cambridge, MA 02139 USA

[5] MIT, Whitehead Inst Biomed Res, Cambridge, MA 02139 USA

[6] Max Planck Gesell, Max Delbruck Lab, D-50829 Cologne, Germany

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2002年 / 99卷 / 23期

关键词：

D O I：

10.1073/pnas.232573899

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Several yeast activators are phosphorylated by SRB10, a cyclin-dependent kinase associated with the transcriptional machinery. Sites of phosphorylation are found outside the activating region in each case, and the modification has different physiological consequences in different cases. We show here that certain acidic transcriptional activating regions contact SRB10 as assayed both in vivo and in vitro. The interaction evidently positions each activator, as it activates transcription, so that it gets phosphorylated by SRB10, and thus a common mechanism targets disparate substrates to the kinase.

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页码：14706 / 14709

页数：4

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