Enhanced fibronectin-mediated cell adhesion of human osteoblast by fibroblast growth factor, FGF-2

被引：33

作者：

Jang, JH ^{[1
]}

Ku, Y ^{[1
]}

Chung, CP ^{[1
]}

Heo, SJ ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Dent, Intellectual Biointerface Engn Ctr, Seoul 110768, South Korea

来源：

BIOTECHNOLOGY LETTERS | 2002年 / 24卷 / 20期

关键词：

cell adhesion; extracellular matrix; FGF-2; fibronectin; signal transduction;

D O I：

10.1023/A:1020617904251

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Using specific recombinant human fibronectin peptide (hFNIII9-10) that contains the binding site for integrin, we found that the fibroblast growth factor, FGF-2, enhances fibronectin-mediated adhesion in human osteoblast-like MG63 cells. The mechanism of the synergistic adhesion was due to the activation of extracellular-regulated kinase (ERK)-type MAPK upon interaction of integrin to hFNIII9-10 and its downstream activation of signaling pathways.

引用

页码：1659 / 1663

页数：5

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