CB1 cannabinoid receptor antagonists for treatment of obesity and prevention of comorbid metabolic disorders

被引：49

作者：

Antel, Jochen ^{[1
]}

Gregory, Peter C. ^{[1
]}

Nordheim, Ulrich ^{[1
]}

机构：

[1] Solvay Pharmaceut Res Labs, Hans Boeckler Allee 20, D-30173 Hannover, Germany

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 49卷 / 14期

关键词：

D O I：

10.1021/jm058238r

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：4008 / 4016

页数：9

共 108 条

[1]

Adam J, 2002, EXPERT OPIN THER PAT, V12, P1475

[2] Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors [J].

Arnone, M ;

Maruani, J ;

Chaperon, F ;

Thiebot, MH ;

Poncelet, M ;

Soubrie, P ;

LeFur, G .

PSYCHOPHARMACOLOGY, 1997, 132 (01) :104-106

[3] The therapeutic potential of cannabis [J].

Baker, D ;

Pryce, G ;

Giovannoni, G ;

Thompson, AJ .

LANCET NEUROLOGY, 2003, 2 (05) :291-298

[4] Current and investigational antiobesity agents and obesity therapeutic treatment targets [J].

Bays, HE .

OBESITY RESEARCH, 2004, 12 (08) :1197-1211

[5] The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells [J].

Bensaid, M ;

Gary-Bobo, M ;

Esclangon, A ;

Maffrand, JP ;

Le Fur, G ;

Oury-Donat, F ;

Soubrié, P .

MOLECULAR PHARMACOLOGY, 2003, 63 (04) :908-914

[6]

Bianchini Franca, 2002, Obes Rev, V3, P5, DOI 10.1046/j.1467-789X.2002.00046.x

[7]

Black Shawn C, 2004, Curr Opin Investig Drugs, V5, P389

[8] Adiponectin:: a relevant player in PPARγ-agonist-mediated improvements in hepatic insulin sensitivity? [J].

Bouskila, M ;

Pajvani, UB ;

Scherer, PE .

INTERNATIONAL JOURNAL OF OBESITY, 2005, 29 (Suppl 1) :S17-S23

[9] CONSTRUCTION OF A 3D MODEL OF THE CANNABINOID CB1 RECEPTOR - DETERMINATION OF HELIX ENDS AND HELIX ORIENTATION [J].

BRAMBLETT, RD ;

PANU, AM ;

BALLESTEROS, JA ;

REGGIO, PH .

LIFE SCIENCES, 1995, 56 (23-24) :1971-1982

[10] Medical consequences of obesity [J].

Bray, GA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (06) :2583-2589

← 1 2 3 4 5 6 7 8 9 10 →