Determination of dihydroergotamine in human plasma by high-performance liquid chromatography with fluorescence detection

被引：3

作者：

Murday, M ^{[1
]}

McLean, AM ^{[1
]}

Slaughter, E ^{[1
]}

Couch, RA ^{[1
]}

机构：

[1] Shire Labs Inc, Rockville, MD 20850 USA

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 1999年 / 735卷 / 02期

关键词：

dihydroergotamine;

D O I：

10.1016/S0378-4347(99)00405-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Dihydroergotamine, a 5-hydroxytryptamine antagonist, is used for the treatment of vascular headaches. A highperformance liquid chromatography assay with fluorescence detection is described for the determination of dihydroergotamine in plasma. The assay was validated over the concentration range 0.1-10 ng/ml plasma and applied to the analysis of plasma samples from subjects treated intramuscularly and intranasally with 2 mg of dihydroergotamine. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：151 / 157

页数：7

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