Difluoromethylornithine in cancer: new advances

被引：58

作者：

Alexiou, George A. ^{[1
]}

Lianos, Georgios D. ^{[1
]}

Ragos, Vassileios ^{[1
]}

Galani, Vasiliki ^{[2
]}

Kyritsis, Athanassios P. ^{[1
]}

机构：

[1] Univ Ioannina, Sch Med, Inst Neurosurg, GR-45110 Ioannina, Greece

[2] Univ Ioannina, Sch Med, Dept Anat Histol Embryol, GR-45110 Ioannina, Greece

来源：

FUTURE ONCOLOGY | 2017年 / 13卷 / 09期

关键词：

chemoprevention; clinical trial; colorectal cancer; difluoromethylornithine; glioma pancreatic cancer; TARGETING ORNITHINE-DECARBOXYLASE; NONMELANOMA SKIN-CANCER; PHASE-I-II; ALPHA-DIFLUOROMETHYLORNITHINE; COLON-CANCER; PANCREATIC-CANCER; PROSTATE TUMOR; TOPICAL DIFLUOROMETHYLORNITHINE; POSTRADIOTHERAPY CHEMOTHERAPY; CHEMOPREVENTIVE EFFICACY;

D O I：

10.2217/fon-2016-0266

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Difluoromethylornithine (DFMO; eflornithine) is an irreversible suicide inhibitor of the enzyme ornithine decarboxylase which is involved in polyamine synthesis. Polyamines are important for cell survival, thus DFMO was studied as an anticancer agent and as a chemoprevention agent. DFMO exhibited mainly cytostatic activity and had single agent efficacy as well as activity in combination with other chemotherapeutic drugs for some cancers and leukemias. Herewith, we summarize the current knowledge of the anticancer and chemopreventive properties of DFMO and assess the status of clinical trials.

引用

页码：809 / 819

页数：11

共 94 条

[1]

Alberts DS, 2000, CANCER EPIDEM BIOMAR, V9, P1281

[2]

Combination treatment of TRAIL, DFMO and radiation for malignant glioma cells [J].

Alexiou, George A. ;

Tsamis, Konstantinos I. ;

Vartholomatos, Evrysthenis ;

Peponi, Evangelia ;

Tzima, Eftychia ;

Tasiou, Ifigeneia ;

Lykoudis, Efstathios ;

Tsekeris, Pericles ;

Kyritsis, Athanasios P. .

JOURNAL OF NEURO-ONCOLOGY, 2015, 123 (02) :217-224

[3]

Targeting Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL): A Promising Therapeutic Strategy in Gliomas [J].

Alexiou, George A. ;

Tsamis, Konstantinos I. ;

Kyritsis, Athanasios P. .

SEMINARS IN PEDIATRIC NEUROLOGY, 2015, 22 (01) :35-39

[4]

Arbeit JM, 1999, CANCER RES, V59, P3610

[5]

CDK Inhibitors Induce Mitochondria-mediated Apoptosis Through the Activation of Polyamine Catabolic Pathway in LNCaP, DU145 and PC3 Prostate Cancer Cells [J].

Arisan, Elif Damla ;

Obakan, Pinar ;

Coker-Gurkan, Ajda ;

Calcabrini, Annarica ;

Agostinelli, Enzo ;

Unsal, Narcin Palavan .

CURRENT PHARMACEUTICAL DESIGN, 2014, 20 (02) :180-188

[6]

European Code against Cancer, 4th Edition: Cancer screening [J].

Armaroli, Paola ;

Villain, Patricia ;

Suonio, Eero ;

Almonte, Maribel ;

Anttila, Ahti ;

Atkin, Wendy S. ;

Dean, Peter B. ;

de Koning, Harry J. ;

Dillner, Lena ;

Herrero, Rolando ;

Kuipers, Ernst J. ;

Lansdorp-Vogelaar, Iris ;

Minozzi, Silvia ;

Paci, Eugenio ;

Regula, Jaroslaw ;

Tornberg, Sven ;

Segnan, Nereo .

CANCER EPIDEMIOLOGY, 2015, 39 :S139-S152

[7]

Inhibiting Cycloxygenase and Ornithine Decarboxylase by Diclofenac and Alpha-Difluoromethylornithine Blocks Cutaneous SCCs by Targeting Akt-ERK Axis [J].

Arumugam, Aadithya ;

Weng, Zhiping ;

Talwelkar, Sarang S. ;

Chaudhary, Sandeep C. ;

Kopelovich, Levy ;

Elmets, Craig A. ;

Afaq, Farrukh ;

Athar, Mohammad .

PLOS ONE, 2013, 8 (11)

[8]

Targeting Polyamines and Inflammation for Cancer Prevention [J].

Babbar, Naveen ;

Gerner, Eugene W. .

CLINICAL CANCER PREVENTION, 2011, 188 :49-64

[9]

A Randomized, Double-Blind, Placebo-Controlled Phase 3 Skin Cancer Prevention Study of α-Difluoromethylornithine in Subjects with Previous History of Skin Cancer [J].

Bailey, Howard H. ;

Kim, KyungMann ;

Verma, Ajit K. ;

Sielaff, Karen ;

Larson, Paul O. ;

Snow, Stephen ;

Lenaghan, Theresa ;

Viner, Jaye L. ;

Douglas, Jeff ;

Dreckschmidt, Nancy E. ;

Hamielec, Mary ;

Pomplun, Marcy ;

Sharata, Harry H. ;

Puchalsky, David ;

Berg, Eric R. ;

Havighurst, Thomas C. ;

Carbone, Paul P. .

CANCER PREVENTION RESEARCH, 2010, 3 (01) :35-47

[10]

Difluoromethylornithine Is a Novel Inhibitor of Helicobacter pylori Growth, CagA Translocation, and Interleukin-8 Induction [J].

Barry, Daniel P. ;

Asim, Mohammad ;

Leiman, David A. ;

de Sablet, Thibaut ;

Singh, Kshipra ;

Casero, Robert A., Jr. ;

Chaturvedi, Rupesh ;

Wilson, Keith T. .

PLOS ONE, 2011, 6 (02)

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