Common vitamin D pathway gene variants reveal contrasting effects on serum vitamin D levels in African Americans and European Americans

被引:69
作者
Batai, Ken [1 ]
Murphy, Adam B. [2 ,3 ]
Shah, Ebony [1 ]
Ruden, Maria [4 ]
Newsome, Jennifer [5 ]
Agate, Sara [6 ]
Dixon, Michael A. [2 ]
Chen, Hua Yun [7 ]
Deane, Leslie A. [8 ]
Hollowell, Courtney M. P. [9 ]
Ahaghotu, Chiledum [10 ]
Kittles, Rick A. [1 ]
机构
[1] Univ Arizona, Coll Med, Ctr Canc, Div Urol,Dept Surg, Tucson, AZ 85724 USA
[2] Northwestern Univ, Dept Urol, Feinberg Sch Med, Chicago, IL 60611 USA
[3] Jesse Brown Vet Affairs Med Ctr, Chicago, IL USA
[4] Univ Illinois, Dept Med, Chicago, IL USA
[5] Univ Illinois, Ctr Clin & Translat Sci, Chicago, IL USA
[6] Univ Illinois, Sch Publ Hlth, Div Hlth Policy & Adm, Chicago, IL USA
[7] Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, Chicago, IL USA
[8] Rush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
[9] Cook Cty Hlth & Hosp Syst, Dept Surg, Urol Sect, Chicago, IL USA
[10] Howard Univ Hosp, Dept Surg, Div Urol, Washington, DC USA
基金
美国国家卫生研究院;
关键词
D-BINDING PROTEIN; CIRCULATING 25-HYDROXYVITAMIN D; D INSUFFICIENCY; SKIN PIGMENTATION; US POPULATION; D DEFICIENCY; LOW-INCOME; CANCER; ASSOCIATION; DISEASE;
D O I
10.1007/s00439-014-1472-y
中图分类号
Q3 [遗传学];
学科分类号
071007 [遗传学];
摘要
Vitamin D deficiency is more common among African Americans (AAs) than among European Americans (EAs), and epidemiologic evidence links vitamin D status to many health outcomes. Two genome-wide association studies (GWAS) in European populations identified vitamin D pathway gene single-nucleotide polymorphisms (SNPs) associated with serum vitamin D [25(OH) D] levels, but a few of these SNPs have been replicated in AAs. Here, we investigated the associations of 39 SNPs in vitamin D pathway genes, including 19 GWAS-identified SNPs, with serum 25(OH) D concentrations in 652 AAs and 405 EAs. Linear and logistic regression analyses were performed adjusting for relevant environmental and biological factors. The pattern of SNP associations was distinct between AAs and EAs. In AAs, six GWAS-identified SNPs in GC, CYP2R1, and DHCR7/NADSYN1 were replicated, while nine GWAS SNPs in GC and CYP2R1 were replicated in EAs. A CYP2R1 SNP, rs12794714, exhibited the strongest signal of association in AAs. In EAs, however, a different CYP2R1 SNP, rs1993116, was the most strongly associated. Our models, which take into account genetic and environmental variables, accounted for 20 and 28 % of the variance in serum vitamin D levels in AAs and EAs, respectively.
引用
收藏
页码:1395 / 1405
页数:11
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