Vascular Endothelial Growth Factor

被引：511

作者：

Ferrara, Napoleone ^{[1
]}

机构：

[1] Genentech Inc, San Francisco, CA 94080 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2009年 / 29卷 / 06期

关键词：

TUMOR ANGIOGENESIS; PERMEABILITY FACTOR; TYROSINE KINASE; CELLS SECRETE; IN-VIVO; VEGF; DISORDERS; LETHALITY; RECEPTOR; MITOGEN;

D O I：

10.1161/ATVBAHA.108.179663

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration. This brief review provides a historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis. (Arterioscler Thromb Vasc Biol. 2009;29:789-791.)

引用

收藏

页码：789 / 791

页数：3

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