Studies on the biological effects of ozone: 10. Release of factors from ozonated human platelets

被引：54

作者：

Valacchi, G ^{[1
]}

Bocci, V ^{[1
]}

机构：

[1] Univ Siena, Inst Gen Physiol, I-53100 Siena, Italy

来源：

MEDIATORS OF INFLAMMATION | 1999年 / 8卷 / 4-5期

关键词：

ozone; platelets; aggregation; growth factors; inteleukin-8;

D O I：

10.1080/09629359990360

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

IN a previous work we have shown that heparin, in the presence of ozone (O-3), promotes a dose-dependent platelet aggregation, while after Ca2+ chelation with citrate, platelet aggregation is almost negligible. These results led us to think that aggregation may enhance the release of platelet components. We have here shown that indeed significantly higher amount of platelet-derived growth factor (PDGF), transforming growth factor beta 1 (TGF-beta 1) and interleukin-8(IL-8) are released in a dose-dependent manner after ozonation of heparinised platelet-rich plasma samples. These findings may explain the enhanced healing of torpid ulcers in patients with chronic Limb ischemia treated with O-3 autohaemoteraphy (O-3-AHT).

引用

页码：205 / 209

页数：5

共 16 条

[1]

Bocci V, 1999, PLATELETS, V10, P110

[2]

Bocci V, 1996, J BIOL REG HOMEOS AG, V10, P31

[3]

Bocci V, 1998, PERSPECT BIOL MED, V42, P131

[4] OXYGEN RADICAL SCAVENGERS SELECTIVELY INHIBIT INTERLEUKIN-8 PRODUCTION IN HUMAN WHOLE-BLOOD [J].