Glucose regulated proteins in cancer progression, drug resistance and immunotherapy

被引：207

作者：

Fu, Yong ^{[1
]}

Lee, Amy S. ^{[1
]}

机构：

[1] Univ So Calif, Keck Sch Med, USC Norris Comprehens Canc Ctr, Dept Biochem & Mol Biol, Los Angeles, CA 90089 USA

来源：

CANCER BIOLOGY & THERAPY | 2006年 / 5卷 / 07期

关键词：

glucose regulated proteins; GRP78; GRP94; GRP170; tumor proliferation; drug resistance; prognosis; immunotherapy;

D O I：

10.4161/cbt.5.7.2970

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It has been established that as molecular chaperones, the glucose-regulated proteins (GRPs) play an important role in maintaining cellular homeostasis. This conventional concept of GRPs as protein folding chaperones is updated by discoveries that GRPs promote tumor proliferation, metastasis, drug resistance, immunotherapy, which have major clinical implications in the prognosis and treatment of cancer. Further, the localization of GRPs on the cell surface of certain cell types suggests that they serve new functions as cell surface receptors for signaling. These and other new developments on the role of GRP78, GRP94 and GRP170 in cancer progression and therapy are discussed in this review.

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收藏

页码：741 / 744

页数：4

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