Novel Schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cells

被引：366

作者：

Adsule, Shreelekha

Barve, Vivek

Chen, Di

Ahmed, Fakhara

Dou, Q. Ping

Padhye, Subhash

Sarkar, Fazlul H.

机构：

[1] Wayne State Univ, Sch Med, Barbara Ann Karmanos Canc Inst, Dept Pathol, Detroit, MI 48201 USA

[2] Wayne State Univ, Sch Med, Barbara Ann Karmanos Canc Inst, Prevent Program, Detroit, MI 48201 USA

[3] Univ Pune, Dept Chem, Pune 411007, Maharashtra, India

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 49卷 / 24期

关键词：

D O I：

10.1021/jm060712l

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

We report the synthesis of novel 1: 1 Schiff base copper complexes of quinoline-2-carboxaldehyde showing dose-dependent, antiproliferative, and proapoptotic activity in PC-3 and LNCaP prostate cancer cells. We found that quinoline thiosemicarbazone 2 (FPA-137) was the most potent and inhibited proteosome activity in intact human prostate cancer PC-3 and LNCaP cells (IC50 of 4 and 3.2 mu M, respectively) compared to clioquinol and pyrrolidine dithiocarbamate (IC50 of 10 and 20 mu M), supporting the novelty of 2.

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页码：7242 / 7246

页数：5

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