A randomised double-blind clinical trial of two yellow fever vaccines prepared with substrains 17DD and 17D-213/77 in children nine-23 months old

被引：24

作者：

Collaborative Group for Studies of Yellow Fever Vaccine

Camacho L.A.B. ^{[2
,4
]}

Freire M.S. ^{[4
]}

Leal M.L.F. ^{[4
]}

Maia M.L.S. ^{[4
]}

Martins R.M. ^{[4
]}

Sato H.K. ^{[5
]}

Fernandes G.C. ^{[6
,8
,10
]}

de Castro I.P. ^{[7
]}

Ribeiro J.G.L. ^{[8
]}

Lemos J.C. ^{[8
]}

de Barros E.O.M. ^{[9
]}

Yoshida A.M.Y. ^{[3
]}

Igushi T. ^{[2
,4
]}

Leitão M.B. ^{[8
]}

Batista M. ^{[8
,10
]}

Barros M.C. ^{[9
]}

Emilia N. ^{[9
]}

Paganini E. ^{[5
]}

Nascimento M. ^{[4
]}

da Silva N. ^{[4
]}

Pereira N.F. ^{[11
]}

Renoiner E.I.M. ^{[11
]}

Rocha M.F. ^{[12
]}

Galdino M.A. ^{[12
]}

Barbosa L.M.M. ^{[13
]}

Costa Z.G.A. ^{[11
]}

机构：

[1] Fundacao Oswaldo Cruz, Inst Tecnol Imunobiol, Assessoria Clin, Rio De Janeiro, RJ, Brazil

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2015年 / 110卷 / 06期

关键词：

yellow fever vaccine; randomised clinical trial; immunogenicity; COMBINED VACCINATION; MEASLES-VACCINES; FIELD TRIAL; IMMUNOGENICITY; IMMUNIZATION; INFANTS; SAFETY; ANTIBODIES; VIRUS;

D O I：

10.1590/0074-02760150176

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程]; 100103 [病原生物学];

摘要：

This randomised, double-blind, multicentre study with children nine-23 months old evaluated the immunogenicity of yellow fever (YF) vaccines prepared with substrains 17DD and 17D-213/77. YF antibodies were tittered before and 30 or more days after vaccination. Seropositivity and seroconversion were analysed according to the maternal serological status and the collaborating centre. A total of 1,966 children were randomised in the municipalities of the states of Mato Grosso do Sul, Minas Gerais and Sao Paulo and blood samples were collected from 1,714 mothers. Seropositivity was observed in 78.6% of mothers and 8.9% of children before vaccination. After vaccination, seropositivity rates of 81.9% and 83.2%, seroconversion rates of 84.8% and 85.8% and rates of a four-fold increase over the pre-vaccination titre of 77.6% and 81.8% were observed in the 17D-213/77 and 17DD subgroups, respectively. There was no association with maternal immunity. Among children aged 12 months or older, the seroconversion rates of 69% were associated with concomitant vaccination against measles, mumps and rubella. The data were not conclusive regarding the interference of maternal immunity in the immune response to the YF vaccine, but they suggest interference from other vaccines. The failures in seroconversion after vaccination support the recommendation of a booster dose in children within 10 years of the first dose.

引用

页码：771 / 780

页数：10

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