Detection of a Sexually Transmitted Hepatitis C Virus Protease Inhibitor-Resistance Variant in a Human Immunodeficiency Virus-Infected Homosexual Man

被引：51

作者：

Franco, Sandra ^{[1
]}

Tural, Cristina ^{[2
,3
,4
,5
]}

Nevot, Maria ^{[1
]}

Molto, Jose ^{[2
,3
,4
,5
]}

Kurt Rockstroh, Juergen ^{[6
]}

Clotet, Bonaventura ^{[1
,2
,3
,4
,5
]}

Angel Martinez, Miguel ^{[1
]}

机构：

[1] Fundacio IrsiCaixa, Badalona, Spain

[2] Hosp Badalona Germans Trias & Pujol, Dept Internal Med, Badalona 08916, Spain

[3] Univ Autonoma Barcelona, E-08193 Barcelona, Spain

[4] Univ Vic UVic Barcelona, Barcelona, Spain

[5] Fundacio Lluita SIDA, Badalona, Spain

[6] Bonn Univ Hosp, Dept Med 1, Bonn, Germany

来源：

GASTROENTEROLOGY | 2014年 / 147卷 / 03期

关键词：

Liver Disease; Cirrhosis; Transmission;

D O I：

10.1053/j.gastro.2014.05.010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

There is an international epidemic of hepatitis C virus (HCV) infection among human immunodeficiency virus-infected men who have sex with men. Transmission of HCV variants that are resistant to recently approved direct-acting antivirals (DAAs) could be an important clinical and public health problem. We document a case of transmission of a DAA-resistant variant of HCV from a patient who was treated with telaprevir to his sexual partner. The transmission of HCV DAA-resistant variants could impair therapeutic regimens that include DAAs.

引用

页码：599 / +

页数：4

共 10 条

[1]

Complexity and Catalytic Efficiency of Hepatitis C Virus (HCV) NS3 and NS4A Protease Quasispecies Influence Responsiveness to Treatment with Pegylated Interferon plus Ribavirin in HCV/HIV-Coinfected Patients [J].

Aparicio, Ester ;

Franco, Sandra ;

Parera, Mariona ;

Andres, Cristina ;

Tural, Cristina ;

Clotet, Bonaventura ;

Angel Martinez, Miguel .

JOURNAL OF VIROLOGY, 2011, 85 (12) :5961-5969

[2]

Diagnosis and Treatment of Acute Hepatitis C Virus Infection [J].

Boesecke, Christoph ;

Wedemeyer, Heiner ;

Rockstroh, Juergen Kurt .

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 2012, 26 (04) :995-+

[3]

Hepatitis C Viral Evolution in Genotype 1 Treatment-Naive and Treatment-Experienced Patients Receiving Telaprevir-Based Therapy in Clinical Trials [J].

Kieffer, Tara L. ;

De Meyer, Sandra ;

Bartels, Doug J. ;

Sullivan, James C. ;

Zhang, Eileen Z. ;

Tigges, Ann ;

Dierynck, Inge ;

Spanks, Joan ;

Dorrian, Jennifer ;

Jiang, Min ;

Adiwijaya, Bambang ;

Ghys, Anne ;

Beumont, Maria ;

Kauffman, Robert S. ;

Adda, Nathalie ;

Jacobson, Ira M. ;

Sherman, Kenneth E. ;

Zeuzem, Stefan ;

Kwong, Ann D. ;

Picchio, Gaston .

PLOS ONE, 2012, 7 (04)

[4]

Hepatitis C virus reinfection incidence and treatment outcome among HIV-positive MSM [J].

Martin, Thomas C. S. ;

Martin, Natasha K. ;

Hickman, Matthew ;

Vickerman, Peter ;

Page, Emma E. ;

Everett, Rhiannon ;

Gazzard, Brian G. ;

Nelson, Mark .

AIDS, 2013, 27 (16) :2551-2557

[5]

Hepatitis C virus NS3/4A quasispecies diversity in acute hepatitis C infection in HIV-1 co-infected patients [J].

Nevot, M. ;

Boesecke, C. ;

Parera, M. ;

Andres, C. ;

Franco, S. ;

Revollo, B. ;

Ingiliz, P. ;

Tural, C. ;

Clotet, B. ;

Rockstroh, J. K. ;

Martinez, M. A. .

JOURNAL OF VIRAL HEPATITIS, 2014, 21 (06) :E19-E28

[6]

Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir [J].

Sarrazin, Christoph ;

Kieffer, Tara L. ;

Bartels, Doug ;

Hanzelka, Brian ;

Muh, Ute ;

Welker, Martin ;

Wincheringer, Dennis ;

Zhou, Yi ;

Chu, Hui-May ;

Lin, Chao ;

Weegink, Christine ;

Reesink, Henk ;

Zeuzem, Stefan ;

Kwong, Ann D. .

GASTROENTEROLOGY, 2007, 132 (05) :1767-1777

[7]

Evolution of Treatment-Emergent Resistant Variants in Telaprevir Phase 3 Clinical Trials [J].

Sullivan, James C. ;

De Meyer, Sandra ;

Bartels, Doug J. ;

Dierynck, Inge ;

Zhang, Eileen Z. ;

Spanks, Joan ;

Tigges, Ann M. ;

Ghys, Anne ;

Dorrian, Jennifer ;

Adda, Nathalie ;

Martin, Emily C. ;

Beumont, Maria ;

Jacobson, Ira M. ;

Sherman, Kenneth E. ;

Zeuzem, Stefan ;

Picchio, Gaston ;

Kieffer, Tara L. .

CLINICAL INFECTIOUS DISEASES, 2013, 57 (02) :221-229

[8]

MEGA4: Molecular evolutionary genetics analysis (MEGA) software version 4.0 [J].

Tamura, Koichiro ;

Dudley, Joel ;

Nei, Masatoshi ;

Kumar, Sudhir .

MOLECULAR BIOLOGY AND EVOLUTION, 2007, 24 (08) :1596-1599

[9]

Evidence of a Large, International Network of HCV Transmission in HIV-Positive Men Who Have Sex With Men [J].

van de Laar, Thijis ;

Pybus, Oliver ;

Bruisten, Sylvia ;

Brown, David ;

Nelson, Mark ;

Bhagani, Sanjay ;

Vogel, Martin ;

Baumgarten, Alex ;

Chaix, Marie-Laure ;

Fisher, Martin ;

Gotz, Hannelore ;

Matthews, Gail V. ;

Neifer, Stefan ;

White, Peter ;

Rawlinson, William ;

Pol, Stanislav ;

Rockstroh, Jurgen ;

Coutinho, Roel ;

Dore, Greg J. ;

Dusheiko, Geoffrey M. ;

Danta, M. .

GASTROENTEROLOGY, 2009, 136 (05) :1609-1617

[10]

Hepatitis C Virus Infections in the Swiss HIV Cohort Study: A Rapidly Evolving Epidemic [J].

Wandeler, Gilles ;

Gsponer, Thomas ;

Bregenzer, Andrea ;

Guenthard, Huldrych F. ;

Clerc, Olivier ;

Calmy, Alexandra ;

Stoeckle, Marcel ;

Bernasconi, Enos ;

Furrer, Hansjakob ;

Rauch, Andri .

CLINICAL INFECTIOUS DISEASES, 2012, 55 (10) :1408-1416

← 1 →