Homogeneous time-resolved fluoroimmunoassay for the measurement of midregional proadrenomedullin in plasma on the fully automated system BRAHMS KRYPTOR®

被引：69

作者：

Caruhel, Pascaline ^{[1
]}

Mazier, Christian ^{[1
]}

Kunde, Jan ^{[2
]}

Morgenthaler, Nils G. ^{[2
]}

Darbouret, Bruno ^{[1
]}

机构：

[1] CEZANNE SAS, Dept Res & Dev, F-30035 Nimes 1, France

[2] BRAHMS AG, Res Dept, Ctr Biotechnol, Hennigsdorf, Germany

来源：

CLINICAL BIOCHEMISTRY | 2009年 / 42卷 / 7-8期

关键词：

MR-proADM; KRYPTOR; Automation; Heart failure; Community-acquired pneumonia; REGIONAL PRO-ADRENOMEDULLIN; PEPTIDE; SEPSIS;

D O I：

10.1016/j.clinbiochem.2009.01.002

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objectives: Evaluate the first automated assay measuring a mid regional fragment of the proadrenomedullin (MR-proADM). Design and methods: B.R.A.H.M.S MR-proADM KRYPTOR(R) is a homogeneous assay. Results: In 144 healthy individuals, MR-proADM mean (SD) was measured at 0.37 nmol/L (0.09). High correlation with the manual assay, B.R.A.H.M.S MR-proADM LIA, was found on 281 samples from patients suffering from community acquired pneumonia (correlation coefficient 0.97). Conclusions: This fast assay can be used in low respiratory tract infections. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：725 / 728

页数：4

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