Locoregional treatments for hepatocellular carcinoma

被引:18
作者
Bruix, J [1 ]
Llovet, JM [1 ]
机构
[1] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer, Liver Unit,Barcelona Clin Liver Canc Grp, Catalonia, Spain
关键词
hepatocellular carcinoma; locoregional treatment; percutaneous ethanol injection; thermal ablation; arterial embolization;
D O I
10.1053/bega.1999.0051
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Improvements in diagnostic techniques have enhanced our understanding of the natural history of hepatocellular carcinoma (HCC). This has facilitated a proper evaluation of the available treatment options for this neoplasm through both phase II studies and randomized controlled trials. Surgical resection and liver transplantation constitute the first two radical options, and when they are contra-indicated, patients may benefit from percutaneous ethanol injection or thermal ablation by radiofrequency current. These options may also achieve a complete response and constitute the last potentially radical therapies for small HCC. In contrast, for large multinodular tumours, the available treatment options have not been shown to improve survival. Arterial embolization with or without associated chemotherapy has been widely used. However, randomized controlled trials have failed to show a survival benefit, emphasizing the need to develop new treatment strategies.
引用
收藏
页码:611 / 622
页数:12
相关论文
共 71 条
[1]  
Arora AS, 1996, J CELL PHYSIOL, V167, P434, DOI 10.1002/(SICI)1097-4652(199606)167:3<434::AID-JCP7>3.0.CO
[2]  
2-Q
[3]   Resection of hepatocellular carcinoma in patients with cirrhosis [J].
Balsells, J ;
Charco, R ;
Lazaro, JL ;
Murio, E ;
Vargas, V ;
Allende, E ;
Margarit, C .
BRITISH JOURNAL OF SURGERY, 1996, 83 (06) :758-761
[4]   INTRAHEPATIC RECURRENCE AFTER RESECTION OF HEPATOCELLULAR-CARCINOMA COMPLICATING CIRRHOSIS [J].
BELGHITI, J ;
PANIS, Y ;
FARGES, O ;
BENHAMOU, JP ;
FEKETE, F .
ANNALS OF SURGERY, 1991, 214 (02) :114-117
[5]   LIVER RESECTION VERSUS TRANSPLANTATION FOR HEPATOCELLULAR-CARCINOMA IN CIRRHOTIC-PATIENTS [J].
BISMUTH, H ;
CHICHE, L ;
ADAM, R ;
CASTAING, D ;
DIAMOND, T ;
DENNISON, A .
ANNALS OF SURGERY, 1993, 218 (02) :145-151
[6]   Diagnostic value and tolerance of Lipiodol-computed tomography for the detection of small hepatocellular carcinoma: correlation with pathologic examination of explanted livers [J].
Bizollon, TR ;
Rode, A ;
Bancel, B ;
Gueripel, V ;
Ducerf, C ;
Baulieux, J ;
Trepo, C .
JOURNAL OF HEPATOLOGY, 1998, 28 (03) :491-496
[7]  
Boix L., 1996, Hepatology, V24, p349A
[8]   HEMODYNAMIC EVALUATION OF THE PATIENT WITH PORTAL-HYPERTENSION [J].
BOSCH, J ;
MASTAI, R ;
KRAVETZ, D ;
NAVASA, M ;
RODES, J .
SEMINARS IN LIVER DISEASE, 1986, 6 (04) :309-317
[9]   Transarterial embolization versus symptomatic treatment in patients with advanced hepatocellular carcinoma:: Results of a randomized, controlled trial in a single institution [J].
Bruix, J ;
Llovet, JM ;
Castells, A ;
Montañá, X ;
Brú, C ;
Ayuso, MD ;
Vilana, R ;
Rodés, J .
HEPATOLOGY, 1998, 27 (06) :1578-1583
[10]   PHASE-II STUDY OF TRANSARTERIAL EMBOLIZATION IN EUROPEAN PATIENTS WITH HEPATOCELLULAR-CARCINOMA - NEED FOR CONTROLLED TRIALS [J].
BRUIX, J ;
CASTELLS, A ;
MONTANYA, X ;
CALVET, X ;
BRU, C ;
AYUSO, C ;
JOVER, L ;
GARCIA, L ;
VILANA, R ;
BOIX, L ;
RODES, J .
HEPATOLOGY, 1994, 20 (03) :643-650