Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae)

被引：77

作者：

Asano, N

Nishida, M

Miyauchi, M

Ikeda, K

Yamamoto, M

Kizu, H

Kameda, Y

Watson, AA

Nash, RJ

Fleet, GWJ

机构：

[1] Hokuriku Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9201181, Japan

[2] AFRC, Inst Grassland & Environm Res, Aberystwyth SY23 3EB, Dyfed, Wales

[3] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

来源：

PHYTOCHEMISTRY | 2000年 / 53卷 / 03期

关键词：

Adenophora triphylla var. japonica; Campanulaceae; 1,4-dideoxy-1,4-imino-D-arabinitol (D-AB1); 6-C-butyl-DMDP; 1-deoxynojirimycin; 1-deoxymannojirimycin; alpha-1-C-ethyl-fagomine; glycosidase inhibitors;

D O I：

10.1016/S0031-9422(99)00555-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adenophora triphylla var. japonica (Campanulaceae) yielded two new alkaloids, the 6-C-butyl derivative of 2R,5R-bis(hydroxymethyl)-3R,4R-dihydroxypyrrolidine (DMDP) and alpha-1-C-ethyl-fagomine, together with the known alkaloids 1,4dideoxy-1,4-imino-D-arabinitol, 1-deoxynojirimycin, and 1-deoxymannojirimycin. 6-C-Butyl-DMDP showed inhibitory activity toward almond beta-glucosidase (IC50 = 68 mu M), whereas alpha-1-C-ethyl-fagomine inhibited bovine liver beta-galactosidase (IC50 = 29 mu M) (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：379 / 382

页数：4

共 9 条

[1] SUGARS WITH NITROGEN IN THE RING ISOLATED FROM THE LEAVES OF MORUS-BOMBYCIS [J].