A Red Carpet for Iron Metabolism

被引：1192

作者：

Muckenthaler, Martina U. ^{[1
,2
,3
]}

Rivella, Stefano ^{[4
]}

Hentze, Matthias W. ^{[1
,2
,5
]}

Galy, Bruno ^{[6
]}

机构：

[1] European Mol Biol Lab, Mol Med Partnership Unit, Neuenheimer Feld 350, D-69120 Heidelberg, Germany

[2] Heidelberg Univ, Neuenheimer Feld 350, D-69120 Heidelberg, Germany

[3] Dept Pediat Oncol Hematol & Immunol, Neuenheimer Feld 153, D-69120 Heidelberg, Germany

[4] Childrens Hosp Philadelphia, 3615 Civ Ctr Blvd, Philadelphia, PA 19104 USA

[5] European Mol Biol Lab, Meyerhofstr 1, D-69117 Heidelberg, Germany

[6] German Canc Res Ctr, Div Virus Associated Carcinogenesis F170, Neuenheimer Feld 280, D-69120 Heidelberg, Germany

来源：

CELL | 2017年 / 168卷 / 03期

基金：

美国国家卫生研究院;

关键词：

LACKING TRANSFERRIN RECEPTOR; BETA-THALASSEMIA; HEPCIDIN EXPRESSION; DOWN-REGULATION; MOUSE MODEL; REGULATORY PROTEINS; H-FERRITIN; RESPONSIVE ELEMENT; POLYCYTHEMIA-VERA; CHAPERONES PCBP1;

D O I：

10.1016/j.cell.2016.12.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

200 billion red blood cells (RBCs) are produced every day, requiring more than 2 x 10(15) iron atoms every second to maintain adequate erythropoiesis. These numbers translate into 20 mL of blood being produced each day, containing 6 g of hemoglobin and 20 mg of iron. These impressive numbers illustrate why the making and breaking of RBCs is at the heart of iron physiology, providing an ideal context to discuss recent progress in understanding the systemic and cellular mechanisms that underlie the regulation of iron homeostasis and its disorders.

引用

页码：344 / 361

页数：18

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