Effects of the partial glycine agonist D-cycloserine on cognitive functioning in chronic low dose MPTP-treated monkeys

被引:44
作者
Schneider, JS [1 ]
Tinker, JP [1 ]
Van Velson, M [1 ]
Giardiniere, M [1 ]
机构
[1] Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA
关键词
monkey; NMDA; glycine; cognition; MPTP;
D O I
10.1016/S0006-8993(00)02036-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
D-Cycloserine, a partial agonist at the glycine recognition site of the N-methyl-D-aspartate (NMDA) receptor complex, has been shown to facilitate certain forms of memory formation and to improve visual recognition memory in normal monkeys. In the present study, the effects of D-cycloserine on spatial short-term memory deficits in monkeys induced by chronic low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration were examined. Chronic low-dose MPTP administration resulted in deficits in the performance of a variable delayed-response task (VDR). Single administration of D-cycloserine (320 or 1000 mu g/kg) significantly improved the performance on this task. High-dose D-cycloserine (8000 mu g/kg) or MK-801 (10-32 mu g/kg) administration had no effects on delayed-response performance but impaired performance on a visual discrimination (VD) task that was not adversely affected by MPTP administration. These results show that at low doses, D-cycloserine has cognition-enhancing properties in this model of early Parkinsonism. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:190 / 194
页数:5
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