Effect of valproate on cerebral metabolism and blood flow: An F-18-2-deoxyglusose and O-15 water positron emission tomography study

被引:95
作者
Gaillard, WD
Zeffiro, T
Fazilat, S
DeCarli, C
Theodore, WH
机构
[1] NINCDS,EPILEPSY RES BRANCH,NIH,BETHESDA,MD
[2] NIA,NEUROSCI LAB,NIH,BETHESDA,MD 20892
关键词
valproate; positron emission tomography; cerebral blood flow; cerebral metabolism;
D O I
10.1111/j.1528-1157.1996.tb00602.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We compared the effect of valproate (VPA) on cerebral metabolic rate for glucose (CMRGlc) and cerebral blood flow (CBF), measured with F-18-2-deoxyglucose ((18)FDG) and O-15 water positron emission tomography (PET), in 10 normal volunteers. Mean VPA dose was 17.7 mg/kg, and mean VPA level was 82.1 mg/L (+/-16.5) for 4 weeks. VPA reduced global CMRGlc by 9.4% (9.60 +/- 0.76 vs. 8.59 +/- 1.02 mg Glc/min/100 g, p < 0.05) and regionally in all anatomic areas (p < 0.05 for 11 of 26 areas), VPA diminished global CBF by 14.9% (56.55 +/- 6.70 vs. 47.48 +/- 4.42 ml/min/100 g, p < 0.002) and regionally in all anatomic areas (p < 0.05 for 12 of 26 areas). No significant correlation was noted between VPA level and either global CMRGlc or CBF. The effect of VPA on global CMRGlc is similar to that of carbamazepine (CBZ) and phenytoin but less than that of phenobarbital, valium, or combination therapy with VPA and CBZ. VPA reduced regional CBF (rCBF) but not CMRGlc in the thalamus, an effect that may be associated with VPA's mechanism of action against generalized seizures.
引用
收藏
页码:515 / 521
页数:7
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