Leishmanicidal activity of withajardins and acnistins.: An experimental and computational study

被引：8

作者：

Cardona, Diana

Quinones, Winston

Torres, Fernando

Robledo, Sara

Velez, Ivan Dario

Cruz, Victor

Notario, Rafael

Echeverri, Fernando

机构：

[1] Univ Antioquia, SIU, Grp Quim Organ Prod Nat, Medellin, Colombia

[2] Univ Antioquia, SIU, PECET, Medellin, Colombia

[3] CSIC, Inst Estructura Mat, E-28006 Madrid, Spain

[4] CSIC, Inst Quim Fis Rocasolano, E-28006 Madrid, Spain

来源：

TETRAHEDRON | 2006年 / 62卷 / 29期

关键词：

withanolides; leishmanicidal activity; 3D-QSAR; cytotoxicity; lactone;

D O I：

10.1016/j.tet.2006.04.101

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Several acnistins and withajardins were studied in their action against Leishmania (V) panamensis amastigotes; leishmanicidal activity and high toxicity were found. The 3D-QSAR analysis reveals certain correlation between bioactivity and some steric and electrostatic characteristics around the A and B rings of the steroidal skeleton; however, the models predict the same effects for both leishmanicidal and toxicity activities. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：6822 / 6829

页数：8

共 22 条

[1]

The Cambridge Structural Database: a quarter of a million crystal structures and rising [J].