Interactions Between the Dietary Polyunsaturated Fatty Acid Ratio and Genetic Factors Determine Susceptibility to Pediatric Crohn's Disease

被引：74

作者：

Costea, Irina ^{[1
]}

Mack, David R. ^{[2
]}

Lemaitre, Rozenn N. ^{[3
]}

Israel, David ^{[4
]}

Marcil, Valerie ^{[5
]}

Ahmad, Ali ^{[6
,8
]}

Amre, Devendra K. ^{[7
,8
]}

机构：

[1] Publ Hlth Agcy Canada, Montreal, PQ, Canada

[2] Childrens Hosp Eastern Ontario, Div Gastroenterol, Ottawa, ON K1H 8L1, Canada

[3] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA

[4] British Columbia Childrens Hosp, Div Gastroenterol Hepatol & Nutr, Vancouver, BC, Canada

[5] McGill Univ, Res Inst, Montreal, PQ, Canada

[6] Univ Montreal, Dept Microbiol & Immunol, Quebec City, PQ, Canada

[7] Univ Montreal, Dept Pediat, Quebec City, PQ, Canada

[8] Le Ctr Hosp Univ Ste Justine, Res Ctr, Montreal, PQ, Canada

来源：

GASTROENTEROLOGY | 2014年 / 146卷 / 04期

关键词：

DNA; Inflammatory Bowel Disease; Fat Content; Food; INFLAMMATORY BOWEL-DISEASE; LEUKOTRIENE-B4; ASSOCIATION;

D O I：

10.1053/j.gastro.2013.12.034

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Increased dietary ratios of u6/u3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of u6/u3, confers susceptibility to CD. Based on data from 182 children newly diagnosed with CD and 250 controls, we found that children who consumed a higher dietary ratio of u6/u3 were susceptible for CD if they were also carriers of specific variants of CYP4F3 and FADS2 genes. Our findings implicate diet-gene interactions in the pathogenesis of CD.

引用

页码：929 / U443

页数：6

共 18 条

[1] Imbalances in dietary consumption of fatty acids, vegetables, and fruits are associated with risk for crohn's disease in children [J].

Amre, Devendra K. ;

D'Souza, Savio ;

Morgan, Kenneth ;

Seidman, Gillian ;

Lambrette, Philippe ;

Grimard, Guy ;

Israel, David ;

Mack, David ;

Ghadirian, Parviz ;

Deslandres, Colette ;

Chotard, Virginie ;

Budai, Balint ;

Law, Liliane ;

Levy, Emile ;

Seidman, Ernest G. .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2007, 102 (09) :2016-2025

[2] Omega-3 fatty acids and inflammatory bowel diseases - a systematic review [J].

Cabre, Eduard ;

Manosa, Miriam ;

Gassull, Miquel A. .

BRITISH JOURNAL OF NUTRITION, 2012, 107 :S240-S252

[3] Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale [J].

Calder, Philip C. .

BIOCHIMIE, 2009, 91 (06) :791-795

[4] Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium [J].

Carlson, CS ;

Eberle, MA ;

Rieder, MJ ;

Yi, Q ;

Kruglyak, L ;

Nickerson, DA .

AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 74 (01) :106-120

[5]

Corcos Laurent, 2012, Drug Metabolism and Drug Interactions, V27, P63, DOI [10.1515/DMDI-2011-0037, 10.1515/dmdi-2011-0037]

[6] The PPAR alpha-leukotriene B-4 pathway to inflammation control [J].

Devchand, PR ;

Keller, H ;

Peters, JM ;

Vazquez, M ;

Gonzalez, FJ ;

Wahli, W .

NATURE, 1996, 384 (6604) :39-43

[7] COLORECTAL LEUKOTRIENE-B4 SYNTHESIS INVITRO IN INFLAMMATORY BOWEL-DISEASE - INHIBITION BY THE SELECTIVE 5-LIPOXYGENASE INHIBITOR BWA4C [J].

HAWTHORNE, AB ;

BOUGHTONSMITH, NK ;

WHITTLE, BJR ;

HAWKEY, CJ .

GUT, 1992, 33 (04) :513-517

[8] Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease [J].

Jostins, Luke ;

Ripke, Stephan ;

Weersma, Rinse K. ;

Duerr, Richard H. ;

McGovern, Dermot P. ;

Hui, Ken Y. ;

Lee, James C. ;

Schumm, L. Philip ;

Sharma, Yashoda ;

Anderson, Carl A. ;

Essers, Jonah ;

Mitrovic, Mitja ;

Ning, Kaida ;

Cleynen, Isabelle ;

Theatre, Emilie ;

Spain, Sarah L. ;

Raychaudhuri, Soumya ;

Goyette, Philippe ;

Wei, Zhi ;

Abraham, Clara ;

Achkar, Jean-Paul ;

Ahmad, Tariq ;

Amininejad, Leila ;

Ananthakrishnan, Ashwin N. ;

Andersen, Vibeke ;

Andrews, Jane M. ;

Baidoo, Leonard ;

Balschun, Tobias ;

Bampton, Peter A. ;

Bitton, Alain ;

Boucher, Gabrielle ;

Brand, Stephan ;

Buening, Carsten ;

Cohain, Ariella ;

Cichon, Sven ;

D'Amato, Mauro ;

De Jong, Dirk ;

Devaney, Kathy L. ;

Dubinsky, Marla ;

Edwards, Cathryn ;

Ellinghaus, David ;

Ferguson, Lynnette R. ;

Franchimont, Denis ;

Fransen, Karin ;

Gearry, Richard ;

Georges, Michel ;

Gieger, Christian ;

Glas, Juergen ;

Haritunians, Talin ;

Hart, Ailsa .

NATURE, 2012, 491 (7422) :119-124

[9] Genome-wide association study identifies multiple loci influencing human serum metabolite levels [J].

Kettunen, Johannes ;

Tukiainen, Taru ;

Sarin, Antti-Pekka ;

Ortega-Alonso, Alfredo ;

Tikkanen, Emmi ;

Lyytikainen, Leo-Pekka ;

Kangas, Antti J. ;

Soininen, Pasi ;

Wuertz, Peter ;

Silander, Kaisa ;

Dick, Danielle M. ;

Rose, Richard J. ;

Savolainen, Markku J. ;

Viikari, Jorma ;

Kahonen, Mika ;

Lehtimaki, Terho ;

Pietilainen, Kirsi H. ;

Inouye, Michael ;

McCarthy, Mark I. ;

Jula, Antti ;

Eriksson, Johan ;

Raitakari, Olli T. ;

Salomaa, Veikko ;

Kaprio, Jaakko ;

Jarvelin, Marjo-Riitta ;

Peltonen, Leena ;

Perola, Markus ;

Freimer, Nelson B. ;

Ala-Korpela, Mika ;

Palotie, Aarno ;

Ripatti, Samuli .

NATURE GENETICS, 2012, 44 (03) :269-U65

[10]

Lemaitre RN, 2012, PLOS GENET, V7

← 1 2 →