Clinical implications of E-cadherin associated hereditary diffuse gastric cancer

被引：74

作者：

Fitzgerald, RC ^{[1
]}

Caldas, C ^{[1
]}

机构：

[1] Hutchison MRC Res Ctr, Cambridge CB2 2XZ, England

来源：

GUT | 2004年 / 53卷 / 06期

关键词：

D O I：

10.1136/gut.2003.022061

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Approximately 1-3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. These may be of the diffuse or intestinal type. Linkage analysis has recently implicated E-cadherin mutations in an estimated 25% of families with an autosomal dominant predisposition to diffuse type gastric cancers. This subset of gastric cancer has been termed hereditary diffuse gastric cancer (HDGC).

引用

页码：775 / 778

页数：4

共 41 条

[1]

BECKER KF, 1994, CANCER RES, V54, P3845

[2] FREQUENT SOMATIC ALLELIC INACTIVATION OF THE E-CADHERIN GENE IN GASTRIC CARCINOMAS [J].