Tailored recombinant elastin-like polymers for advanced biomedical and nano(bio)technological applications

被引:43
作者
Arias, F. Javier [1 ]
Reboto, Virginia [1 ]
Martin, Susana [1 ]
Lopez, Isabel [1 ]
Rodriguez-Cabello, J. Carlos [1 ]
机构
[1] Univ Valladolid, ETSII, Dept Fis Mat Condensada, BIOFORGE Res Grp, E-47011 Valladolid, Spain
关键词
elastin-like polymers; genetic engineering; nanobiotechnology; protein-based polymers; smart polymers; tissue engineering;
D O I
10.1007/s10529-006-9045-3
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The genetic engineering of protein-based polymers is a method that enables, in an easy way, the design of complex and highly functional macromolecules. As examples of this approach, different molecular designs are presented, with increasing degree of complexity, showing how the controlled increase in their complexity yields (multi)functional materials with more selected and sophisticated properties. The simplest designs show interesting properties already, but the adequate introduction of given chemical functions along the polymer chain provides an opportunity to expand the range of properties to enhanced smart behavior and self-assembly. Finally, examples are given where those molecular designs further incorporate selected bioactivities in order to develop materials for the most cutting edge applications in biomedicine and nano(bio)technology.
引用
收藏
页码:687 / 695
页数:9
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